谷胱甘肽 S-转移酶 T1 基因缺失型与高加索人前列腺癌风险增加相关：一项荟萃分析。

GSTT1 null genotype is associated with an increased risk of prostate cancer in caucasians: a meta-analysis.

作者信息

Zhu Jianguo, Chen Weihong, Xu Shuxiong, Wang Yuanlin, Sun Zhaolin

机构信息

Department of Urology, The People's Hospital of Guizhou Province, Guiyang, PR China.

出版信息

Urol Int. 2013;91(1):113-20. doi: 10.1159/000345420. Epub 2013 Jan 18.

DOI:10.1159/000345420

PMID:23343819

Abstract

BACKGROUND

Many studies have investigated the association between glutathione S-transferase T1 (GSTT1) null genotype and the risk of prostate cancer (PCa), but the impact of GSTT1 null genotype on PCa risk in Caucasians is still unclear owing to the inconsistency of such studies. The present study aimed to quantify the strength of association between GSTT1 null genotype and the risk of PCa in Caucasians.

METHODS

We searched the PubMed, Embase and Web of Science databases for studies assessing the association between GSTT1 null genotype and the risk of PCa in Caucasians. We estimated the summary odds ratio (OR) with the corresponding 95% confidence interval (95% CI) to assess the association.

RESULTS

16 case-control studies with 11,648 subjects were included in this meta-analysis. Meta-analysis of a total of 16 studies showed GSTT1 null genotype was significantly associated with an increased risk of PCa in Caucasians (random-effects OR 1.30, 95% CI 1.10-1.53, p = 0.002). After adjustment for heterogeneity, GSTT1 null genotype was still associated with an increased risk of PCa in Caucasians (fixed-effects OR 1.33, 95% CI 1.17-1.52, p < 0.001). The cumulative meta-analyses of all 16 studies showed a trend of more obvious association as information accumulated by year.

CONCLUSIONS

Meta-analysis of available data suggests the GSTT1 null genotype is significantly associated with an increased risk of PCa in Caucasians.

摘要

背景

许多研究调查了谷胱甘肽S-转移酶T1（GSTT1）缺失基因型与前列腺癌（PCa）风险之间的关联，但由于此类研究结果不一致，GSTT1缺失基因型对高加索人群PCa风险的影响仍不明确。本研究旨在量化GSTT1缺失基因型与高加索人群PCa风险之间的关联强度。

方法

我们检索了PubMed、Embase和Web of Science数据库，以查找评估GSTT1缺失基因型与高加索人群PCa风险之间关联的研究。我们估计了汇总比值比（OR）及其相应的95%置信区间（95%CI），以评估这种关联。

结果

本荟萃分析纳入了16项病例对照研究，共11648名受试者。对总共16项研究的荟萃分析表明，GSTT1缺失基因型与高加索人群PCa风险增加显著相关（随机效应OR 1.30，95%CI 1.10 - 1.53，p = 0.002）。在对异质性进行调整后，GSTT1缺失基因型仍与高加索人群PCa风险增加相关（固定效应OR 1.33，95%CI 1.17 - 1.52，p < 0.001）。所有16项研究的累积荟萃分析表明，随着年份积累信息，关联趋势更加明显。