Zhang Qing-Hui, Yao Yong-Liang, Gu Tao, Gu Jin-Hua, Chen Ling, Liu Yun
Department of Clinical Laboratory, Kunshan First People's Hospital, Affiliated to Jiangsu University, Kunshan, Jiangsu, China.
Asian Pac J Cancer Prev. 2012;13(6):2867-71. doi: 10.7314/apjcp.2012.13.6.2867.
Multiple studies have reported associations between the PSCA rs2294008 C>T polymorphism and GC, but susceptibility has proven inconsistent. Therefore, we estimates the relationship between the rs2294008 C>T polymorphism and GC by meta-analysis.
PubMed, Embase and Web of Science databases were searched and nine independent case-control studies were included in this meta- analysis. Crude ORs with 95% CIs were extracted according to the Mantal-Haenszel method and pooled to assess the strength of the association.
We observed that the PSCA rs2294008 C>T polymorphism was significantly correlated with GC risk when all studies were pooled into the meta-analysis. Further subgroup analysis showed the polymorphism to be linked with diffuse and noncardia GC in the allele contrast model, homozygote codominant model, dominant model, and recessive model. However, no connection was apparent for intestinal and cardia GC. In the stratified analysis by ethnicity, significant associations were observed in Asians for the recessive model. Interestingly, the relationship was particularly significant in the Chinese population.
Our findings suggest that the PSCA rs2294008 C>T polymorphism is a risk factor for GC, especially in diffuse and noncardia GC and in Chinese.
多项研究报道了前列腺干细胞抗原（PSCA）基因rs2294008 C>T多态性与胃癌（GC）之间的关联，但结果显示易感性并不一致。因此，我们通过荟萃分析评估rs2294008 C>T多态性与GC之间的关系。
检索了PubMed、Embase和Web of Science数据库，并纳入了9项独立的病例对照研究进行该荟萃分析。根据Mantal-Haenszel方法提取具有95%置信区间（CI）的粗比值比（OR）并进行合并，以评估关联强度。
当将所有研究纳入荟萃分析时，我们观察到PSCA rs2294008 C>T多态性与GC风险显著相关。进一步的亚组分析显示，在等位基因对比模型、纯合子共显性模型、显性模型和隐性模型中，该多态性与弥漫性和非贲门GC相关。然而，与肠型和贲门GC无明显关联。在按种族进行的分层分析中，亚洲人在隐性模型中存在显著关联。有趣的是，在中国人群中这种关系尤为显著。
我们的研究结果表明，PSCA rs2294008 C>T多态性是GC的一个危险因素，尤其是在弥漫性和非贲门GC以及中国人中。
