Schlegelberger B, Feller A, Himmler A, Grote W
Department of Human Genetics, Christian Albrecht University, Kiel, Federal Republic of Germany.
Cancer Genet Cytogenet. 1990 Jan;44(1):77-81. doi: 10.1016/0165-4608(90)90200-t.
A case of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) with four cytogenetically different cell clones (49,XX,+5,+19,+21/47,XX,+X/46,XX,inv (14)(q11q32)/45,X,-X) is reported. To our knowledge, this is the first case of AILD with an inv(14)(q11q32), thus probably involving the T-cell receptor alpha-chain gene. The cytogenetic findings are discussed with respect to the possible progression of AILD to malignant lymphoma.
报告了一例伴有异常蛋白血症的血管免疫母细胞性淋巴结病（AILD），其具有四个细胞遗传学不同的细胞克隆（49,XX,+5,+19,+21/47,XX,+X/46,XX,inv(14)(q11q32)/45,X,-X）。据我们所知，这是首例伴有inv(14)(q11q32)的AILD病例，因此可能涉及T细胞受体α链基因。结合AILD向恶性淋巴瘤可能的进展情况对细胞遗传学结果进行了讨论。
