Blank M, Palestine A, Nussenblatt R, Shoenfeld Y
Department of Medicine D, Soroka Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Clin Immunol Immunopathol. 1990 Jan;54(1):87-97. doi: 10.1016/0090-1229(90)90008-e.
The administration of cyclosporine A, cyclosporine A plus bromocriptine, or bromocriptine results in down-regulation of antinuclear autoantibody levels in the sera of patients with uveitis. Decreased levels of autoantibodies against DNA, histones, cardiolipin, RNP, Sm, Ro (SS-A), and La (SS-B) were detected in the sera of patients with uveitis receiving cyclosporine A or cyclosporine A plus bromocriptine following 3 months of treatment. In contrast to the decreased antibody titers obtained following the treatment, the total immunoglobulin levels remained within the normal range. The results indicate that cyclosporine may affect B cell function, thereby yielding the observed decrease in autoantibody levels. This phenomenon might have clinical importance as a serological indicator of the efficiency of the patients to respond to the drug.
给予环孢素A、环孢素A加溴隐亭或溴隐亭可使葡萄膜炎患者血清中的抗核自身抗体水平下调。在接受环孢素A或环孢素A加溴隐亭治疗3个月后的葡萄膜炎患者血清中，检测到针对DNA、组蛋白、心磷脂、核糖核蛋白、Sm、Ro（SS - A）和La（SS - B）的自身抗体水平降低。与治疗后抗体滴度降低形成对比的是，总免疫球蛋白水平仍保持在正常范围内。结果表明，环孢素可能影响B细胞功能，从而导致观察到的自身抗体水平下降。这种现象作为患者对药物反应效率的血清学指标可能具有临床重要性。
