单链 RNA 激活 RNA 干扰途径。

Singles engage the RNA interference pathway.

出版信息

Cell. 2012 Aug 31;150(5):873-5. doi: 10.1016/j.cell.2012.08.008.

DOI:10.1016/j.cell.2012.08.008

Abstract

Single-stranded RNAs interact with components of the RNA interference pathway to reduce the expression of target mRNAs. Now, Lima et al. and Yu et al. show that, with extensive chemical modifications, small single-stranded RNAs can robustly induce gene silencing with efficacy similar to their double-stranded counterparts.

摘要

单链 RNA 与 RNA 干扰途径的成分相互作用，从而降低靶 mRNA 的表达。现在，Lima 等人和 Yu 等人表明，经过广泛的化学修饰，小单链 RNA 可以强有力地诱导基因沉默，其功效与双链 RNA 类似。