非编码 RNA 的基因调控。
Gene regulation by non-coding RNAs.
机构信息
Program for RNA Biology, Sanford-Burnham Medical Research Institute , La Jolla, CA , USA .
出版信息
Crit Rev Biochem Mol Biol. 2014 Jan-Feb;49(1):16-32. doi: 10.3109/10409238.2013.844092. Epub 2013 Oct 28.
Abstract
The past two decades have seen an explosion in research on non-coding RNAs and their physiological and pathological functions. Several classes of small (20-30 nucleotides) and long (>200 nucleotides) non-coding RNAs have been firmly established as key regulators of gene expression in myriad processes ranging from embryonic development to innate immunity. In this review, we focus on our current understanding of the molecular mechanisms underlying the biogenesis and function of small interfering RNAs (siRNAs), microRNAs (miRNAs) and Piwi-interacting RNAs (piRNAs). In addition, we briefly review the relevance of small and long non-coding RNAs to human physiology and pathology and their potential to be exploited as therapeutic agents.
摘要
过去二十年见证了对非编码 RNA 及其生理和病理功能的研究爆炸式增长。几类小（20-30 个核苷酸）和长（>200 个核苷酸）非编码 RNA 已被确定为从胚胎发育到先天免疫等多种过程中基因表达的关键调节剂。在这篇综述中，我们重点介绍了我们对小干扰 RNA (siRNA)、microRNA (miRNA) 和 Piwi 相互作用 RNA (piRNA) 的生物发生和功能的分子机制的理解。此外，我们还简要回顾了小和长非编码 RNA 与人类生理学和病理学的相关性及其作为治疗剂的潜力。
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