大脑发育和可塑性中的主要组织相容性复合体 I 类蛋白。
Major histocompatibility complex class I proteins in brain development and plasticity.
机构信息
Center for Neuroscience, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
出版信息
Trends Neurosci. 2012 Nov;35(11):660-70. doi: 10.1016/j.tins.2012.08.001. Epub 2012 Aug 30.
Abstract
Proper development of the central nervous system (CNS) requires the establishment of appropriate connections between neurons. Recent work suggests that this process is controlled by a balance between synaptogenic molecules and proteins that negatively regulate synapse formation and plasticity. Surprisingly, many of these newly identified synapse-limiting molecules are classic 'immune' proteins. In particular, major histocompatibility complex class I (MHCI) molecules regulate neurite outgrowth, the establishment and function of cortical connections, activity-dependent refinement in the visual system, and long-term and homeostatic plasticity. This review summarizes our current understanding of MHCI expression and function in the CNS, as well as the potential mechanisms used by MHCI to regulate brain development and plasticity.
摘要
中枢神经系统（CNS）的正常发育需要神经元之间建立适当的连接。最近的研究表明，这个过程受到突触生成分子和负调控突触形成和可塑性的蛋白质之间的平衡控制。令人惊讶的是，许多新确定的限制突触形成的分子是经典的“免疫”蛋白。特别是，主要组织相容性复合体 I 类（MHCI）分子调节轴突生长、皮质连接的建立和功能、视觉系统中活性依赖性的精细化以及长期和动态的可塑性。这篇综述总结了我们目前对 CNS 中 MHCI 表达和功能的理解，以及 MHCI 调节大脑发育和可塑性的潜在机制。
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