Vayssade M, Tatar Z, Soubrier M
Service de rhumatologie, hôpital Gabriel-Montpied, CHU de Clermont-Ferrand, 58, boulevard Montalembert, BP 69, 63003 Clermont-Ferrand cedex 1, France.
Rev Med Interne. 2013 Jan;34(1):47-52. doi: 10.1016/j.revmed.2012.07.016. Epub 2012 Aug 29.
Palindromic rheumatism is characterized by episodes of arthritis or para-arthritis leaving no residual or radiographic changes. Several diseases should be ruled out in the differential diagnosis. Evolution to rheumatoid arthritis is common, especially in patient with positive rheumatoid factor and anticitrullinated peptides. In seronegative patients, palindromic rheumatism could be part of the spectrum of autoinflammatory diseases because of a high frequency of MEFV mutations. Treatment remains discussed. The use of antimalarials could delay the development of rheumatoid arthritis or another connective tissue disease.
回纹型风湿症的特点是关节炎或关节周围炎发作后不留残余或影像学改变。鉴别诊断时应排除几种疾病。发展为类风湿关节炎很常见，尤其是类风湿因子和抗瓜氨酸化肽呈阳性的患者。在血清阴性的患者中，由于MEFV突变频率较高，回纹型风湿症可能是自身炎症性疾病谱的一部分。治疗仍存在争议。使用抗疟药可能会延缓类风湿关节炎或其他结缔组织疾病的发展。
