Warren R H, Alderson S H
Pediatric Pulmonary Medicine Section, Arkansas Children's Hospital, Little Rock 72202.
Crit Care Med. 1990 Jan;18(1):92-6. doi: 10.1097/00003246-199001000-00019.
We measured breathing patterns utilizing a respiratory inductive plethysmograph (RIP) in seven healthy nonsedated lambs after an iv infusion of oleic acid (50 mg/kg) to induce acute pulmonary edema. Our single position graphic (SPG) calibration technique was employed for gain factor calculation. Accuracy was validated by the simultaneous volume measurement of RIP and integrated pneumotachography (PNT). Of a total 840 validation breaths, 467 (56%) were within 5% of PNT, 734 (87%) were within 10%, and 834 (99.9%) were within 20%. In each study baseline physiologic and breathing pattern data were collected and also at 15, 30, 60, 90, 150, and 210 min postoleic acid infusion. Validation of RIP accuracy before each data collection revealed 29% required new gain factor calculation. Recalibration was done within 5 min. Excluding respiratory frequency, which remained at 30% above baseline, variables were not significantly different than baseline measurements at the 210-min interval. Results suggest that calibration of RIP using our SPG technique is a time-efficient method and that RIP can accurately measure breathing patterns, providing an additional tool for assessment of experimental lung injury in lambs.
我们在7只健康未镇静的羔羊静脉输注油酸（50mg/kg）以诱导急性肺水肿后，使用呼吸感应体积描记器（RIP）测量呼吸模式。我们采用单位置图形（SPG）校准技术来计算增益因子。通过同时测量RIP和综合呼吸流速描记法（PNT）的体积来验证准确性。在总共840次验证呼吸中，467次（56%）与PNT的误差在5%以内，734次（87%）在10%以内，834次（99.9%）在20%以内。在每项研究中，在油酸输注前以及输注后15、30、60、90、150和210分钟收集基线生理和呼吸模式数据。每次数据收集前对RIP准确性的验证显示，29%需要重新计算增益因子。重新校准在5分钟内完成。除呼吸频率比基线高出30%外，在210分钟时各变量与基线测量值无显著差异。结果表明，使用我们的SPG技术对RIP进行校准是一种省时的方法，并且RIP可以准确测量呼吸模式，为评估羔羊实验性肺损伤提供了一种额外的工具。
