State Bureau of Criminal Investigation Schleswig-Holstein, Section Narcotics/Toxicology, Mühlenweg 166, D-24116 Kiel, Germany.
Forensic Sci Int. 2012 Nov 30;223(1-3):97-105. doi: 10.1016/j.forsciint.2012.08.011. Epub 2012 Aug 30.
In analogy to our previously published procedure for the differentiation of regioisomeric fluoroamphetamines a method was developed, to differentiate ring positional isomeric fluorocathinones by product ion spectrometry of ions generated by chemical ionization (CI) under GC-MS conditions using methane as reagent gas. N-alkylated ortho-, meta- and para-fluorocathinones could be unequivocally differentiated by product ion spectrometry of the hydrogen fluoride loss ions M+H-HF using a triple quadrupole mass spectrometer with argon as collision gas under normalized collision conditions. This method enables the differentiation of ring positional isomers of fluorocathinones even in complex mixtures and low concentrations. The applicability of the method was shown by the analysis of synthesized N-alkylated ortho-, meta- and para-fluorocathinones and seized designer drug mixtures.
类似于我们之前发表的用于区分氟苯丙胺对映异构体的程序，开发了一种方法，通过使用甲烷作为试剂气在 GC-MS 条件下的化学电离 (CI) 生成的离子的产物离子谱来区分环状位置异构氟苯丙胺。使用带有氩气作为碰撞气体的三重四极杆质谱仪，在归一化碰撞条件下，通过对 [M+H-HF]+（HF 失去离子）的产物离子谱进行分析，可以明确地区分 N-烷基化邻位、间位和对位氟苯丙胺。即使在复杂混合物和低浓度下，该方法也能够区分氟苯丙胺的环状位置异构体。该方法的适用性通过对合成的 N-烷基化邻位、间位和对位氟苯丙胺以及缴获的设计药物混合物的分析得到了证明。
