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传染病与白血病和非霍奇金淋巴瘤风险:病例对照研究。

Infectious diseases and risk of leukemia and non-Hodgkin's lymphoma: a case-control study.

机构信息

Unit of Epidemiology, Biostatistics and Clinical Trials, IRCCS AOU San Martino-IST, Genoa, Italy.

出版信息

Leuk Res. 2012 Nov;36(11):1354-8. doi: 10.1016/j.leukres.2012.08.016. Epub 2012 Aug 31.

Abstract

The aim of this investigation was to evaluate the association between common infectious diseases and the risk of hematological malignancies in an adult population. Data were drawn from a population based case-control study that included 165 cases (125 lymphoid and 40 myeloid neoplasms) and 233 controls. Occurrence of childhood diseases (measles, rubella, chickenpox, mumps, pertussis and scarlet fever) was slightly inversely associated with the risk of both malignancies, but statistical significance was not reached. The data of infections occurring after 14 years of age indicated an increasing risk of lymphoid malignancies (OR=2.9, p<0.05).

摘要

本研究旨在评估成人人群中常见传染病与血液系统恶性肿瘤风险之间的关联。数据来自一项基于人群的病例对照研究,该研究纳入了 165 例病例(125 例淋巴系统恶性肿瘤和 40 例髓系恶性肿瘤)和 233 例对照。儿童时期疾病(麻疹、风疹、水痘、腮腺炎、百日咳和猩红热)的发生与两种恶性肿瘤的风险呈轻微负相关,但未达到统计学意义。14 岁后发生的感染数据表明,淋巴系统恶性肿瘤的风险呈上升趋势(OR=2.9,p<0.05)。

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