Miligi Lucia, Costantini Adele Seniori, Bolejack Vanessa, Veraldi Angela, Benvenuti Alessandra, Nanni Oriana, Ramazzotti Valerio, Tumino Rosario, Stagnaro Emanuele, Rodella Stefania, Fontana Arabella, Vindigni Carla, Vineis Paolo
Environmental and Occupational Epidemiology Unit, Center for Study and Prevention of Cancer, Florence, Italy.
Am J Ind Med. 2003 Dec;44(6):627-36. doi: 10.1002/ajim.10289.
The etiology of non-Hodgkin's lymphoma (NHL) and leukemia is still largely unknown, but exposure to chemicals, in particular pesticides, has been suggested to be a risk factor.
A large population-based case-control study was conducted in Italy with the aim of investigating the associations between pesticide exposure and NHL, and solvents and leukemia. Data presented in this article refer to 1,575 interviewed cases and 1,232 controls in the nine agricultural study areas.
Exposure to nitro-derivatives and phenylimides among fungicides, hydrocarbon derivatives and insecticide oils among insecticides, and the herbicide amides are the chemical classes observed to be associated with the pathologies under investigation.
The results of the case-control study suggest an increased risk for NHL and leukemia, and some chemical classes of pesticides, although few are statistically significant and some are based on few exposed cases. The results also show that men and women experience both similar and different risks for the same environmental agricultural exposures. Am. J. Ind. Med. 44:627-636, 2003.
非霍奇金淋巴瘤（NHL）和白血病的病因在很大程度上仍不明确，但接触化学物质，尤其是农药，被认为是一个风险因素。
在意大利开展了一项基于人群的大型病例对照研究，旨在调查农药接触与NHL以及溶剂与白血病之间的关联。本文呈现的数据涉及九个农业研究区域的1575名受访病例和1232名对照。
在杀菌剂中，硝基衍生物和苯酰亚胺、杀虫剂中的烃类衍生物和杀虫油以及除草剂酰胺被观察到与所研究的疾病有关。
病例对照研究结果表明，NHL和白血病风险增加，某些农药化学类别与此有关，尽管少数在统计学上具有显著意义，且部分基于少量暴露病例。结果还表明，男性和女性在相同的农业环境暴露中面临相似和不同的风险。《美国工业医学杂志》2003年第44卷：627 - 636页
