非霍奇金淋巴瘤、白血病与农业接触：意大利多中心病例对照研究结果

Non-Hodgkin's lymphoma, leukemia, and exposures in agriculture: results from the Italian multicenter case-control study.

作者信息

Miligi Lucia, Costantini Adele Seniori, Bolejack Vanessa, Veraldi Angela, Benvenuti Alessandra, Nanni Oriana, Ramazzotti Valerio, Tumino Rosario, Stagnaro Emanuele, Rodella Stefania, Fontana Arabella, Vindigni Carla, Vineis Paolo

机构信息

Environmental and Occupational Epidemiology Unit, Center for Study and Prevention of Cancer, Florence, Italy.

出版信息

Am J Ind Med. 2003 Dec;44(6):627-36. doi: 10.1002/ajim.10289.

DOI:10.1002/ajim.10289

PMID:14635239

Abstract

BACKGROUND

The etiology of non-Hodgkin's lymphoma (NHL) and leukemia is still largely unknown, but exposure to chemicals, in particular pesticides, has been suggested to be a risk factor.

METHODS

A large population-based case-control study was conducted in Italy with the aim of investigating the associations between pesticide exposure and NHL, and solvents and leukemia. Data presented in this article refer to 1,575 interviewed cases and 1,232 controls in the nine agricultural study areas.

RESULTS

Exposure to nitro-derivatives and phenylimides among fungicides, hydrocarbon derivatives and insecticide oils among insecticides, and the herbicide amides are the chemical classes observed to be associated with the pathologies under investigation.

CONCLUSIONS

The results of the case-control study suggest an increased risk for NHL and leukemia, and some chemical classes of pesticides, although few are statistically significant and some are based on few exposed cases. The results also show that men and women experience both similar and different risks for the same environmental agricultural exposures. Am. J. Ind. Med. 44:627-636, 2003.

摘要