Sen Arpita, Madhivanan Kayalvizhi, Mukherjee Debarati, Aguilar R Claudio
Department of Biological Sciences and Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.
Biomol Concepts. 2012 Apr;3(2):117-126. doi: 10.1515/bmc-2011-0060.
The epsins are a conserved family of endocytic adaptors essential for cell viability in yeast and for embryo development in higher eukaryotes. Epsins function as adaptors by recognizing ubiquitinated cargo and as endocytic accessory proteins by contributing to endocytic network stability/regulation and membrane bending. Importantly, epsins play a critical role in signaling by contributing to epidermal growth factor receptor downregulation and the activation of notch and RhoGTPase pathways. In this review, we present an overview of the epsins and emphasize their functional importance as coordinators of endocytosis and signaling.
Epsin蛋白家族是一类保守的内吞衔接蛋白，对酵母细胞的生存能力以及高等真核生物的胚胎发育至关重要。Epsin蛋白通过识别泛素化的货物发挥衔接蛋白的作用，并通过促进内吞网络的稳定性/调节和膜弯曲来充当内吞辅助蛋白。重要的是，Epsin蛋白通过促进表皮生长因子受体的下调以及Notch和RhoGTPase信号通路的激活，在信号传导中发挥关键作用。在本综述中，我们概述了Epsin蛋白，并强调了它们作为内吞作用和信号传导协调者的功能重要性。
