子宫颈癌和阴道癌的治疗机制
Therapeutic Mechanisms of Treatment in Cervical and Vaginal Cancer.
作者信息
Kunos Charles A
机构信息
Director of Gynecologic Radiation Oncology, Department of Radiation Oncology, University Hospitals Cleveland.
出版信息
Oncol Hematol Rev. 2012 Spring;8(1):55-60.
Abstract
Cervical and vaginal cancers remain serious health problems. Worldwide, more than 530,000 women annually are diagnosed with these diseases, with most new incident cases occurring in nations with limited health resources and underdeveloped screening programs. For women whose disease is too bulky or widespread for surgery, radiochemotherapy should be looked upon as the standard of care. Randomized clinical trials have indicated that radiochemotherapy strategies that disrupt the repair of damaged DNA are key to the management of advanced stage cervical and vaginal cancers. Here, from a viewpoint of cancer cell molecular biology, treatments for advanced stage cervical and vaginal cancers are discussed.
摘要
宫颈癌和阴道癌仍然是严重的健康问题。在全球范围内，每年有超过53万名女性被诊断出患有这些疾病，大多数新发病例发生在卫生资源有限且筛查项目不发达的国家。对于那些疾病过于严重或广泛以至于无法进行手术的女性，放化疗应被视为标准治疗方法。随机临床试验表明，破坏受损DNA修复的放化疗策略是晚期宫颈癌和阴道癌治疗的关键。在此，从癌细胞分子生物学的角度讨论晚期宫颈癌和阴道癌的治疗方法。
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