Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Carbohydr Polym. 2012 Nov 6;90(4):1648-55. doi: 10.1016/j.carbpol.2012.07.045. Epub 2012 Jul 25.
Three dimensionally ordered macroporous (3DOM) chitosan (3D-CS) matrix with interconnected pores in the nanometer range was developed as a drug carrier for the first time. 3D-CS was prepared using a template-assisted assembly and characterized by SEM, TGA, N(2) adsorption and FT-IR. As a model drug, nimodipine (NMDP) was incorporated into the pores of 3D-CS matrix. The solid state properties of NMDP-loaded samples were characterized by SEM, XRD, DSC and FT-IR. Dissolution studies showed that release behavior of the drug was markedly affected by the particle size of the matrix. With a relatively small matrix particle size, formulations of NMDP-3D-CS-0.5 and NMDP-3D-CS-1 exhibited rapid release patterns. However, on increasing the amount of carrier, release rate of the drug decreased. The pH-dependent slow-release characteristic of 3D-CS matrix delivery system was demonstrated by investigating the release behavior of NMDP at different pH values.
首次开发了具有纳米级相互连接孔的三维有序大孔（3DOM）壳聚糖（3D-CS）载体作为药物载体。3D-CS 通过模板辅助组装制备，并通过 SEM、TGA、N2 吸附和 FT-IR 进行了表征。将尼莫地平（NMDP）作为模型药物掺入 3D-CS 基质的孔中。通过 SEM、XRD、DSC 和 FT-IR 对载药样品的固态性质进行了表征。溶出研究表明，药物的释放行为明显受到基质粒径的影响。对于相对较小的基质粒径，NMDP-3D-CS-0.5 和 NMDP-3D-CS-1 的制剂表现出快速释放模式。然而，随着载体量的增加，药物的释放速率降低。通过研究 NMDP 在不同 pH 值下的释放行为，证明了 3D-CS 基质传递系统的 pH 依赖性缓慢释放特性。
