Key Laboratory of Bioorganic Phosphorus Chemistry andChemical Biology (Ministry of Education), Department ofChemistry, Tsinghua University, Beijing, China.
Biol Chem. 2012 Jul;393(7):641-6. doi: 10.1515/hsz-2012-0107.
Human islet amyloid polypeptide (hIAPP) shows an antimicrobial activity towards two types of clinically relevant bacteria. The potency of hIAPP varies with its aggregation states. Circular dichroism was employed to determine the interaction between hIAPP and bacteria lipid membrane mimic. The antimicrobial activity of each aggregate species is associated with their ability to induce membrane disruption. Our findings provide new evidence revealing the antimicrobial activity of amyloid peptide, which suggest a possible connection between amyloid peptides and antimicrobial peptides.
人胰岛淀粉样多肽（hIAPP）对两种临床相关细菌具有抗菌活性。hIAPP 的活性与其聚集状态有关。圆二色性用于确定 hIAPP 与细菌脂质膜模拟物之间的相互作用。每种聚集态物质的抗菌活性与其诱导膜破坏的能力相关。我们的发现提供了揭示淀粉样肽抗菌活性的新证据，提示淀粉样肽与抗菌肽之间可能存在联系。
