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遗传因素在双相情感障碍中的作用:现状。

Involvement of genetic factors in bipolar disorders: current status.

机构信息

Centro Studi Psichiatrici, Provaglio D'Iseo, Italy.

出版信息

Psychiatr Danub. 2012 Sep;24 Suppl 1:S112-6.

PMID:22945201
Abstract

Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in mood, energy, activity levels, and the ability to carry out day-to-day tasks. The involvement of genetic factors has been evaluated through twin, family, linkage and association studies but specific genes that contribute to the illness remain unclear. This study gives an overview of available literature.

摘要

双相情感障碍,又称躁郁症,是一种脑部疾病,会导致情绪、精力、活动水平和日常任务执行能力出现异常波动。通过双胞胎、家庭、连锁和关联研究已经评估了遗传因素的作用,但导致这种疾病的特定基因仍不清楚。本研究概述了现有文献。

相似文献

1
Involvement of genetic factors in bipolar disorders: current status.遗传因素在双相情感障碍中的作用:现状。
Psychiatr Danub. 2012 Sep;24 Suppl 1:S112-6.
2
Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder.基因和环境对双相情感障碍同卵双生子和异卵双生子脑容量的影响。
Arch Gen Psychiatry. 2009 Feb;66(2):142-51. doi: 10.1001/archgenpsychiatry.2008.541.
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Is autoimmune thyroiditis part of the genetic vulnerability (or an endophenotype) for bipolar disorder?自身免疫性甲状腺炎是双相情感障碍遗传易感性(或一种内表型)的一部分吗?
Biol Psychiatry. 2007 Jul 15;62(2):135-40. doi: 10.1016/j.biopsych.2006.08.041. Epub 2006 Dec 4.
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Cognitive function in unaffected twins discordant for affective disorder.情感障碍不一致的未患病双胞胎的认知功能。
Psychol Med. 2006 Aug;36(8):1119-29. doi: 10.1017/S0033291706007896. Epub 2006 May 31.
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The heritability of bipolar affective disorder and the genetic relationship to unipolar depression.双相情感障碍的遗传力及其与单相抑郁症的遗传关系。
Arch Gen Psychiatry. 2003 May;60(5):497-502. doi: 10.1001/archpsyc.60.5.497.
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Genetic and environmental influences on pro-inflammatory monocytes in bipolar disorder: a twin study.双相情感障碍中促炎单核细胞的遗传和环境影响:一项双胞胎研究。
Arch Gen Psychiatry. 2009 Sep;66(9):957-65. doi: 10.1001/archgenpsychiatry.2009.116.
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Heritability of bipolar spectrum disorders. Unity or heterogeneity?双相谱系障碍的遗传度:统一性还是异质性?
J Affect Disord. 2008 Mar;106(3):229-40. doi: 10.1016/j.jad.2007.07.001. Epub 2007 Aug 9.
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A nongenetic basis of cycle frequency in bipolar disorder: study of a monozygotic twin pair.双相情感障碍发作频率的非遗传基础:一对同卵双胞胎的研究
J Psychiatry Neurosci. 1997 Mar;22(2):132-5.
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Nature, nurture and depression: a twin study.天性、教养与抑郁症:一项双胞胎研究。
Psychol Med. 1991 May;21(2):329-35. doi: 10.1017/s0033291700020432.
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Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders.遗传或表观遗传差异导致同卵双胞胎之间出现不一致,作为精神障碍分子基础的线索。
Mol Psychiatry. 2005 Jul;10(7):622-30. doi: 10.1038/sj.mp.4001662.

引用本文的文献

1
The genetics of early-onset bipolar disorder: A systematic review.早发性双相情感障碍的遗传学:一项系统综述。
J Affect Disord. 2015 Sep 15;184:1-12. doi: 10.1016/j.jad.2015.05.017. Epub 2015 May 15.
2
Glutamate receptor mutations in psychiatric and neurodevelopmental disorders.精神疾病和神经发育障碍中的谷氨酸受体突变
Commun Integr Biol. 2014 Jan 1;7(1):e27887. doi: 10.4161/cib.27887. Epub 2014 Feb 6.