• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

All for one, one for all: new combinatorial RNAi therapies combat hepatitis C virus evolution.

作者信息

Grimm Dirk

机构信息

Heidelberg University Hospital, Cluster of Excellence CellNetworks, Department of Infectious Diseases, Virology, Heidelberg, Germany.

出版信息

Mol Ther. 2012 Sep;20(9):1661-1663. doi: 10.1038/mt.2012.173.

DOI:10.1038/mt.2012.173
PMID:22945230
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3437588/
Abstract
摘要

相似文献

1
All for one, one for all: new combinatorial RNAi therapies combat hepatitis C virus evolution.人人为我，我为人人：新型组合式RNA干扰疗法对抗丙型肝炎病毒的进化
Mol Ther. 2012 Sep;20(9):1661-1663. doi: 10.1038/mt.2012.173.
2
Inhibition of hepatitis C virus replication by intracellular delivery of multiple siRNAs by nanosomes.纳米囊泡介导的多 siRNA 细胞内递送抑制丙型肝炎病毒复制。
Mol Ther. 2012 Sep;20(9):1724-1736. doi: 10.1038/mt.2012.107. Epub 2012 May 22.
3
Safe, long-term hepatic expression of anti-HCV shRNA in a nonhuman primate model.在非人灵长类动物模型中安全、长期的抗 HCV shRNA 肝表达。
Mol Ther. 2012 Sep;20(9):1737-1749. doi: 10.1038/mt.2012.119. Epub 2012 Jun 26.
4
Potential applications of siRNA in hepatitis C virus therapy.小干扰RNA在丙型肝炎病毒治疗中的潜在应用。
Curr Opin Investig Drugs. 2006 Feb;7(2):142-6.
5
In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus.靶向丙型肝炎病毒的Dicer - 靶向小干扰RNA的体内治疗潜力
Sci Rep. 2014 Apr 23;4:4750. doi: 10.1038/srep04750.
6
Galactosylated Lipidoid Nanoparticles for Delivery of Small Interfering RNA to Inhibit Hepatitis C Viral Replication In Vivo.半乳糖化脂质纳米颗粒用于递送小干扰 RNA 抑制体内丙型肝炎病毒复制。
Adv Healthc Mater. 2016 Nov;5(22):2931-2941. doi: 10.1002/adhm.201600416. Epub 2016 Oct 24.
7
Opportunities for treating chronic hepatitis B and C virus infection using RNA interference.利用RNA干扰治疗慢性乙型和丙型肝炎病毒感染的机会。
J Viral Hepat. 2007 Jul;14(7):447-59. doi: 10.1111/j.1365-2893.2006.00818.x.
8
[Using RNA interference to treat hepatitis virus: hope for future development].
Zhonghua Gan Zang Bing Za Zhi. 2004 Sep;12(9):555.
9
[Current Guidelines for treatment of hepatitis C. The eradication of HCV as a goal].[丙型肝炎治疗的现行指南。以清除丙型肝炎病毒为目标]
Pharm Unserer Zeit. 2011 Jan;40(1):52-9. doi: 10.1002/pauz.201100400.
10
Silencing of hepatitis C virus replication by a non-viral vector based on solid lipid nanoparticles containing a shRNA targeted to the internal ribosome entry site (IRES).基于含有靶向内部核糖体进入位点（IRES）的短发夹RNA（shRNA）的固体脂质纳米粒的非病毒载体对丙型肝炎病毒复制的沉默作用
Colloids Surf B Biointerfaces. 2016 Oct 1;146:808-17. doi: 10.1016/j.colsurfb.2016.07.026. Epub 2016 Jul 12.

引用本文的文献

1
Up-regulation of microRNA-203 in influenza A virus infection inhibits viral replication by targeting DR1.流感 A 病毒感染中 microRNA-203 的上调通过靶向 DR1 抑制病毒复制。
Sci Rep. 2018 May 1;8(1):6797. doi: 10.1038/s41598-018-25073-9.
2
Pharmacokinetics and biodistribution of recently-developed siRNA nanomedicines.新型小干扰RNA纳米药物的药代动力学与生物分布
Adv Drug Deliv Rev. 2016 Sep 1;104:93-109. doi: 10.1016/j.addr.2015.12.004. Epub 2015 Dec 10.
3
Host-targeting agents in the treatment of hepatitis C: a beginning and an end?宿主靶向药物治疗丙型肝炎：开端还是终结？
Antiviral Res. 2013 Nov;100(2):555-61. doi: 10.1016/j.antiviral.2013.09.020. Epub 2013 Sep 30.
4
Evolution of animal and plant dicers: early parallel duplications and recurrent adaptation of antiviral RNA binding in plants.动植物 dicer 的进化：早期平行复制和植物中抗病毒 RNA 结合的反复适应。
Mol Biol Evol. 2013 Mar;30(3):627-41. doi: 10.1093/molbev/mss263. Epub 2012 Nov 22.

本文引用的文献

1
Safe, long-term hepatic expression of anti-HCV shRNA in a nonhuman primate model.在非人灵长类动物模型中安全、长期的抗 HCV shRNA 肝表达。
Mol Ther. 2012 Sep;20(9):1737-1749. doi: 10.1038/mt.2012.119. Epub 2012 Jun 26.
2
Inhibition of hepatitis C virus replication by intracellular delivery of multiple siRNAs by nanosomes.纳米囊泡介导的多 siRNA 细胞内递送抑制丙型肝炎病毒复制。
Mol Ther. 2012 Sep;20(9):1724-1736. doi: 10.1038/mt.2012.107. Epub 2012 May 22.
3
New targets for antiviral therapy of chronic hepatitis C.慢性丙型肝炎抗病毒治疗的新靶点。
Liver Int. 2012 Feb;32 Suppl 1:9-16. doi: 10.1111/j.1478-3231.2011.02701.x.
4
In vitro characterization of the activity of PF-05095808, a novel biological agent for hepatitis C virus therapy.体外评价 PF-05095808 治疗丙型肝炎病毒的新型生物制剂的活性。
Antimicrob Agents Chemother. 2012 Mar;56(3):1364-75. doi: 10.1128/AAC.05357-11. Epub 2011 Dec 27.
5
The dose can make the poison: lessons learned from adverse in vivo toxicities caused by RNAi overexpression.剂量决定毒性：从RNA干扰过表达引起的体内不良毒性中吸取的教训。
Silence. 2011 Oct 26;2:8. doi: 10.1186/1758-907X-2-8.
6
Effect of combined siRNA of HCV E2 gene and HCV receptors against HCV.HCV E2 基因与 HCV 受体联合 siRNA 对 HCV 的作用。
Virol J. 2011 Jun 10;8:295. doi: 10.1186/1743-422X-8-295.
7
Inhibition of hepatitis C virus replication using adeno-associated virus vector delivery of an exogenous anti-hepatitis C virus microRNA cluster.利用腺相关病毒载体传递外源性抗丙型肝炎病毒 microRNA 簇抑制丙型肝炎病毒复制。
Hepatology. 2010 Dec;52(6):1877-87. doi: 10.1002/hep.23908. Epub 2010 Oct 7.
8
Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver.Argonaute 蛋白是 RNAi 在成年小鼠肝脏中的功效、毒性和持久性的关键决定因素。
J Clin Invest. 2010 Sep;120(9):3106-19. doi: 10.1172/JCI43565. Epub 2010 Aug 9.
9
Optimization of linear double-stranded RNA for the production of multiple siRNAs targeting hepatitis C virus.用于生产靶向丙型肝炎病毒的多种小干扰RNA的线性双链RNA的优化
RNA. 2009 May;15(5):898-910. doi: 10.1261/rna.1268209. Epub 2009 Mar 26.
10
Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi.人工微小RNA减轻短发夹RNA介导的脑毒性：对RNA干扰治疗开发的启示
Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5868-73. doi: 10.1073/pnas.0801775105. Epub 2008 Apr 8.