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All for one, one for all: new combinatorial RNAi therapies combat hepatitis C virus evolution.

作者信息

Grimm Dirk

机构信息

Heidelberg University Hospital, Cluster of Excellence CellNetworks, Department of Infectious Diseases, Virology, Heidelberg, Germany.

出版信息

Mol Ther. 2012 Sep;20(9):1661-1663. doi: 10.1038/mt.2012.173.

Abstract
摘要

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本文引用的文献

1
Safe, long-term hepatic expression of anti-HCV shRNA in a nonhuman primate model.
Mol Ther. 2012 Sep;20(9):1737-1749. doi: 10.1038/mt.2012.119. Epub 2012 Jun 26.
2
Inhibition of hepatitis C virus replication by intracellular delivery of multiple siRNAs by nanosomes.
Mol Ther. 2012 Sep;20(9):1724-1736. doi: 10.1038/mt.2012.107. Epub 2012 May 22.
3
New targets for antiviral therapy of chronic hepatitis C.
Liver Int. 2012 Feb;32 Suppl 1:9-16. doi: 10.1111/j.1478-3231.2011.02701.x.
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In vitro characterization of the activity of PF-05095808, a novel biological agent for hepatitis C virus therapy.
Antimicrob Agents Chemother. 2012 Mar;56(3):1364-75. doi: 10.1128/AAC.05357-11. Epub 2011 Dec 27.
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Effect of combined siRNA of HCV E2 gene and HCV receptors against HCV.
Virol J. 2011 Jun 10;8:295. doi: 10.1186/1743-422X-8-295.
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Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver.
J Clin Invest. 2010 Sep;120(9):3106-19. doi: 10.1172/JCI43565. Epub 2010 Aug 9.
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Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi.
Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5868-73. doi: 10.1073/pnas.0801775105. Epub 2008 Apr 8.

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