调控鞭毛内运输。
Regulating intraflagellar transport.
机构信息
Department of Biology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark.
出版信息
Nat Cell Biol. 2012 Sep;14(9):904-6. doi: 10.1038/ncb2569.
DOI:10.1038/ncb2569
PMID:22945257
Abstract
Kinesin-2 motors mediate anterograde intraflagellar transport (IFT) of IFT particles from the ciliary base to its tip, where particles are remodelled before retrograde transport by dynein 2 motors. Bardet-Biedl syndrome (BBS) and IFT-A proteins are now implicated in regulation of IFT assembly at the ciliary base and tip.
摘要
驱动蛋白-2 分子马达介导从纤毛基部到顶端的正向鞭毛内运输（IFT），IFT 颗粒在被动力蛋白-2 分子马达向相反方向运输之前，在纤毛顶端进行重塑。Bardet-Biedl 综合征（BBS）和 IFT-A 蛋白现在被认为参与调节纤毛基部和顶端的 IFT 组装。
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