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内皮素-1 诱导纹状体缺血后米诺环素治疗和骨髓单核细胞移植。

Minocycline treatment and bone marrow mononuclear cell transplantation after endothelin-1 induced striatal ischemia.

机构信息

Laboratory of Experimental Neuroprotection and Neuroregeneration, Institute of Biological Sciences, Federal University of Pará-Brazil, Rua Augusto Corrêa S/N, Campus do Guamá, 66075-900, Belém, Pará, Brazil.

出版信息

Inflammation. 2013 Feb;36(1):197-205. doi: 10.1007/s10753-012-9535-5.

Abstract

We explored whether the modulation of microglia activation with minocycline is beneficial to the therapeutic actions of bone marrow mononuclear cells (BMMCs) transplanted after experimental stroke. Male Wistar adult rats were divided in four experimental groups: ischemic control saline treated (G1, N = 6), ischemic minocycline treated (G2, N = 5), ischemic BMMC treated (G3, N = 5), and ischemic minocycline/BMMC treated (G4, N = 6). There was a significant reduction in the number of ED1+ cells in G3 animals (51.31 ± 2.41, P < 0.05), but this effect was more prominent following concomitant treatment with minocycline (G4 = 29.78 ± 1.56). There was conspicuous neuronal preservation in the brains of G4 animals (87.97 ± 4.27) compared with control group (G1 = 47.61 ± 2.25, P < 0.05). The behavioral tests showed better functional recovery in animals of G2, G3, and G4, compared with G1 and baseline (P < 0.05). The results suggest that a proper modulation of microglia activity may contribute to a more permissive ischemic environment contributing to increased neuroprotection and functional recovery following striatal ischemia.

摘要

我们探讨了米诺环素对小胶质细胞激活的调节是否有益于实验性中风后骨髓单核细胞(BMMC)移植的治疗作用。雄性 Wistar 成年大鼠分为四组实验:缺血生理盐水处理对照(G1,N=6)、缺血米诺环素处理(G2,N=5)、缺血 BMMC 处理(G3,N=5)和缺血米诺环素/BMMC 处理(G4,N=6)。G3 动物的 ED1+细胞数量明显减少(51.31±2.41,P<0.05),但同时给予米诺环素治疗效果更为显著(G4=29.78±1.56)。与对照组(G1=47.61±2.25,P<0.05)相比,G4 动物的大脑中神经元保存更为明显(87.97±4.27)。行为学测试显示,与 G1 和基线相比,G2、G3 和 G4 组动物的功能恢复更好(P<0.05)。这些结果表明,适当调节小胶质细胞的活性可能有助于增加神经保护和功能恢复,从而在纹状体缺血后形成更允许的缺血环境。

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