Van Den Heuvel Rosette L, Lambrechts Nathalie, Verstraelen Sandra, Nelissen Inge C, Schoeters Greet E R
Environmental Risk and Health Unit-Toxicology, Flemish Institute for Technological Research (VITO N.V.), Centre for Advanced R&D on Alternative Methods (CARDAM), Boeretang 200, 2400, Mol, Belgium,
Exp Suppl. 2012;101:289-314. doi: 10.1007/978-3-7643-8340-4_10.
Chemical sensitization remains an important environmental and occupational health issue. A wide range of substances have been shown to possess the ability to induce skin sensitization or respiratory sensitization. As a consequence, there is a need to have appropriate methods to identify sensitizing agents. Although a considerable investment has been made in exploring opportunities to develop methods for hazard identification and characterization, there are, as yet, no validated nonanimal methods available. A state of the art of the different in vitro approaches to identify contact and respiratory capacity of chemicals is covered in this chapter.
化学致敏仍然是一个重要的环境与职业健康问题。已表明多种物质具有诱发皮肤致敏或呼吸道致敏的能力。因此，需要有合适的方法来识别致敏剂。尽管在探索开发危害识别与特征描述方法的机会方面已投入了大量资金，但目前尚无经过验证的非动物方法。本章涵盖了用于识别化学品接触和呼吸致敏能力的不同体外方法的技术现状。
