Gupta Rubina, Sharma Kiran, Dhiman Umesh Kumar
Department of Dental Surgery, Muzaffarnagar Medical College, Muzaffarnagar, Uttar Pradesh, India.
Indian J Dent Res. 2012 Mar-Apr;23(2):295-6. doi: 10.4103/0970-9290.100460.
To assess the clinical efficacy of a combination of oral midazolam plus low-dose ketamine for reducing anxiety during surgery and in preventing postoperative pain and swelling after the surgical extraction of third molars.
Thirty patients requiring bilateral surgical extraction of mandibular third molars were included in this study. Prior to extraction of the tooth on the right side, a combination of oral midazolam and low-dose ketamine was given to the patient, while this protocol was not followed for extraction of the tooth on the left side. Anxiety levels were checked before surgery. The postoperative pain and swelling and patient's comfort with and without the premedication were compared.
Facial swelling on the postoperative days was lower on the right side than on the left. Pain scores at 30 minutes and 24 hours after surgery were significantly higher on the left side. Also, anxiety during the surgery was less and comfort levels were higher postoperatively when the combination of oral midazolam plus low-dose ketamine was used.
Premedication with midazolam plus low-dose ketamine prior to surgical extraction of third molars can provide the patient with a comfortable procedure and good postoperative analgesia, with less swelling and significantly less pain.
评估口服咪达唑仑联合小剂量氯胺酮在减少手术期间焦虑以及预防下颌第三磨牙拔除术后疼痛和肿胀方面的临床疗效。
本研究纳入了30例需要双侧拔除下颌第三磨牙的患者。在拔除右侧牙齿前，给患者服用口服咪达唑仑和小剂量氯胺酮的组合，而拔除左侧牙齿时未遵循此方案。在手术前检查焦虑水平。比较了术前用药和未用药情况下的术后疼痛、肿胀以及患者的舒适度。
术后右侧面部肿胀程度低于左侧。术后30分钟和24小时时，左侧的疼痛评分显著更高。此外，使用口服咪达唑仑联合小剂量氯胺酮时，手术期间的焦虑较少，术后舒适度更高。
在拔除第三磨牙手术前用咪达唑仑联合小剂量氯胺酮进行术前用药，可为患者提供舒适的手术过程和良好的术后镇痛效果，肿胀更少且疼痛明显减轻。
