School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China.
Chemistry. 2012 Oct 15;18(42):13314-9. doi: 10.1002/chem.201201811. Epub 2012 Sep 3.
Gold nanoparticles were grown on single-walled carbon nanotubes (SWNTs) coated with a thiol-functionalized ionic liquid resulting in the formation of core-shell structures referred to as SWNT-IL-Au nanohybrid materials. The nanohybrid materials were characterized by high-resolution transmission electron microscopy (HR-TEM), Raman-, and UV/Vis absorption spectroscopy. The nanohybrid materials were found to enter lysosomes in HeLa cells and show negligible cytotoxicity. Interestingly, they have an enhanced NIR absorption that is effectively transferred into heat to cause localized hyperthermia, resulting in rapid cell death; overall, the material appears to have excellent properties for photothermal therapeutic applications.
金纳米粒子在巯基功能化离子液体包覆的单壁碳纳米管（SWNTs）上生长，形成了被称为 SWNT-IL-Au 纳米杂化材料的核壳结构。通过高分辨率透射电子显微镜（HR-TEM）、拉曼和紫外/可见吸收光谱对纳米杂化材料进行了表征。研究发现，纳米杂化材料进入 HeLa 细胞的溶酶体中，且细胞毒性可忽略不计。有趣的是，它们具有增强的近红外吸收，可有效转化为热量，从而导致局部过热，导致细胞迅速死亡；总的来说，该材料似乎具有用于光热治疗应用的优异性能。
