血清 YKL-40 在子宫内膜癌中的诊断和预后价值。
The diagnostic and prognostic value of serum YKL-40 in endometrial cancer.
机构信息
Department of Gynecology, The First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China.
出版信息
Arch Gynecol Obstet. 2013 Jan;287(1):111-5. doi: 10.1007/s00404-012-2546-5. Epub 2012 Sep 4.
PURPOSE
To evaluate the diagnostic and prognostic value of serum YKL-40 in endometrial cancer (EC).
METHODS
Serum YKL-40 levels were detected and compared in 34 of the 50 cases with EC before surgery, in 22 of the 34 with EC after surgery, in 30 cases with uterine myoma, and in 30 healthy women as normal controls. Receiver operating characteristics (ROC) curves were adopted for diagnosis and calculation of area under each ROC curve in EC. The progression-free survival (PFS) and overall survival (OS) between YKL-40 positive and negative patients were compared in the follow-up.
RESULTS
The mean pre-operative serum YKL-40 values were significantly higher than that in the uterine myoma cases and in the healthy women (P = 0.000). The mean post-operative serum YKL-40 in the 22 EC cases was significantly lower than pre-operative serum YKL-40 levels in these cases (P = 0.000). There were critical differences between the area under ROC curve for YKL-40 and CA125 (P = 0.053). The PFS and OS for the YKL-40-positive patients were significantly shorter than those for the YKL-40-negative patients.
CONCLUSION
Preliminary investigations have shown that serum YKL-40 level may have a definite clinical value in the diagnosis and prognosis of EC.
目的
评估血清 YKL-40 在子宫内膜癌（EC）中的诊断和预后价值。
方法
检测并比较 50 例 EC 患者术前 34 例、术后 22 例、30 例子宫肌瘤患者和 30 例健康女性的血清 YKL-40 水平。采用受试者工作特征（ROC）曲线对 EC 进行诊断，并计算各 ROC 曲线下的面积。在随访中比较 YKL-40 阳性和阴性患者的无进展生存期（PFS）和总生存期（OS）。
结果
术前血清 YKL-40 平均值明显高于子宫肌瘤病例和健康女性（P = 0.000）。22 例 EC 病例术后血清 YKL-40 平均值明显低于这些病例的术前血清 YKL-40 水平（P = 0.000）。YKL-40 和 CA125 的 ROC 曲线下面积之间存在显著差异（P = 0.053）。YKL-40 阳性患者的 PFS 和 OS 明显短于 YKL-40 阴性患者。
结论
初步研究表明，血清 YKL-40 水平在 EC 的诊断和预后中有一定的临床价值。
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