一种非对映选择性环亚胺环加成策略用于获得多羟基化的吲哚里西啶骨架：（+）-/（-）-扁豆碱和（-）-2-表-甜菊醇的简洁合成。
A diastereoselective cyclic imine cycloaddition strategy to access polyhydroxylated indolizidine skeleton: concise syntheses of (+)-/(-)-lentiginosines and (-)-2-epi-steviamine.
机构信息
Key Laboratory of Drug Targeting, Ministry of Education, and Department of Chemistry of Medicinal Natural Products, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China.
出版信息
J Org Chem. 2012 Sep 21;77(18):7891-900. doi: 10.1021/jo3010777. Epub 2012 Sep 13.
PMID:22946565
Abstract
We describe in this paper the development of a novel diastereoselective cyclic imine cycloaddition strategy to access the polyhydroxylated indolizidine skeleton and its application in the concise syntheses of (+)-/(-)-lentiginosines and (-)-2-epi-steviamine.
摘要
我们在本文中描述了一种新型的非对映选择性环亚胺环加成策略的发展，该策略可用于构建多羟基吲哚利定骨架，并将其应用于(+)-/(-)-扁豆碱和(-)-2-表甜菊醇的简洁合成。
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