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会议现场:降低热激蛋白功能。

Conference scene: taking the heat out of chaperokine function.

机构信息

Department of Academic Rheumatology, Division of Immunology, Inflammatory & Infectious Disease, School of Medicine, Guy's Campus, King's College London, London SE1 1UL, UK.

出版信息

Immunotherapy. 2012 Aug;4(8):773-5. doi: 10.2217/imt.12.78.

DOI:10.2217/imt.12.78
PMID:22947004
Abstract

The field of heat-shock protein (HSP) research has been revitalized when extracellular HSPs were reported in the literature in the 1990s. Emerging findings suggest that HSPs can perform a wide variety of biological functions, more than their traditional role as molecular chaperones. With prominent speakers from various HSP fields, the 1(st) Heat Shock Protein - Multiple Roles in Inflammation, Vaccination and Homeostasis Conference covered topics on intracellular and extracellular HSPs along with the role of bacterial and self-HSPs. This conference, organized by Euroscicon, brought together more than 20 delegates from industry and academia for a lively discussion of the current state of HSP research.

摘要

当 20 世纪 90 年代文献中报道细胞外热休克蛋白 (HSP) 时,HSP 研究领域重新焕发生机。新出现的研究结果表明,HSP 可以发挥多种生物学功能,而不仅仅是其作为分子伴侣的传统作用。本次由 Euroscicon 组织的第一届 HSP-炎症、疫苗接种和动态平衡中的多种作用会议汇集了来自各个 HSP 领域的知名演讲者,涵盖了细胞内和细胞外 HSP 以及细菌和自身 HSP 的作用等主题。该会议召集了 20 多名来自工业界和学术界的代表,就 HSP 研究的现状进行了热烈的讨论。

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1
Conference scene: taking the heat out of chaperokine function.会议现场:降低热激蛋白功能。
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Bioinformatics evaluation of the possibility of heat shock proteins as autoantigens in multiple sclerosis based on molecular mimicry hypothesis.基于分子模拟假说对热休克蛋白作为多发性硬化症自身抗原可能性的生物信息学评估。
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引用本文的文献

1
Hsp60 response in experimental and human temporal lobe epilepsy.实验性和人类颞叶癫痫中的热休克蛋白60反应
Sci Rep. 2015 Mar 24;5:9434. doi: 10.1038/srep09434.
2
Elevated blood Hsp60, its structural similarities and cross-reactivity with thyroid molecules, and its presence on the plasma membrane of oncocytes point to the chaperonin as an immunopathogenic factor in Hashimoto's thyroiditis.血液中热休克蛋白60(Hsp60)水平升高、其与甲状腺分子的结构相似性和交叉反应性,以及其在嗜酸性细胞的质膜上的存在,表明伴侣蛋白是桥本甲状腺炎中的一种免疫致病因素。
Cell Stress Chaperones. 2014 May;19(3):343-53. doi: 10.1007/s12192-013-0460-9. Epub 2013 Sep 22.