Pittard W B, Geddes K M, Sutherland S E, Miller M C, Hollis B W
Department of Pediatrics, Medical University of South Carolina, Charleston 29425.
Am J Dis Child. 1990 Jan;144(1):36-40. doi: 10.1001/archpedi.1990.02150250042028.
With the use of photon absorptiometry, bone mineralization was measured at birth and 8 and 16 weeks after delivery in 12 very-low-birth-weight premature (mean +/- SD gestational age, 31 +/- 1.5 weeks) infants who required minimal medical support. Simultaneously, 19 healthy term infants were studied. Throughout the study, each neonate received modified 84-kJ/30 mL formula containing no added calciferol. The recommended daily allowance (400 IU) of calciferol was given to each infant as an oral supplement. Serum 25-hydroxyvitamin D, calcium, phosphorus, and parathyroid hormone concentrations were monitored biweekly and were normal. Bone mineral content and bone width significantly differed at birth between the term and premature infants. However, by 16 weeks after delivery, the premature infants had exceeded the bone mineral status of the term infants at birth, and their bone mineral content was not significantly lower than that of the term infants. These data indicate improved bone mineralization as compared with previously reported data from very-low-birth-weight neonates.
对12名极低出生体重早产儿（平均胎龄±标准差为31±1.5周）进行了研究，这些婴儿仅需极少的医疗支持。利用光子吸收法，在出生时以及出生后8周和16周测量骨矿化情况。同时，对19名健康足月儿进行了研究。在整个研究过程中，每个新生儿均接受不含添加钙化醇的改良84千焦/30毫升配方奶。将钙化醇的推荐每日摄入量（400国际单位）作为口服补充剂给予每个婴儿。每两周监测一次血清25-羟维生素D、钙、磷和甲状旁腺激素浓度，这些浓度均正常。足月儿和早产儿在出生时的骨矿物质含量和骨宽度存在显著差异。然而，到出生后16周时，早产儿的骨矿状态已超过足月儿出生时的水平，且其骨矿物质含量并不显著低于足月儿。这些数据表明，与先前报道的极低出生体重新生儿的数据相比，骨矿化情况有所改善。
