Han Zhen, Lutsiv Olha, Mulla Sohail, McDonald Sarah D
Department of Obstetrics and Gynecology, First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, Shaanxi Province, People's Republic of China.
Faculty of Health Sciences, McMaster University, Hamilton ON.
J Obstet Gynaecol Can. 2012 Aug;34(8):721-746. doi: 10.1016/S1701-2163(16)35337-3.
Preterm birth (PTB) and low birth weight (LBW) are the leading causes of neonatal morbidity and mortality, but the effect of maternal height on these outcomes continues to be debated. Our objective was to determine the relationships between maternal height and PTB and LBW.
Medline and EMBASE were searched from their inceptions.
Studies with a reference group that assessed the effect of maternal height on PTB (< 37 weeks) and LBW (< 2500 grams) in singletons were included.
Data were extracted independently by two reviewers.
Fifty-six studies were included involving 333 505 women. In the cohort studies, the unadjusted risk of PTB in short-statured women was increased (relative risk [RR] 1.23; 95% CI 1.11 to 1.37), as was the unadjusted risk of LBW (RR 1.81; 95% CI 1.47 to 2.23), although not all of the studies with adjusted data found the same association. Maternal tall stature was not associated with PTB (unadjusted RR 0.97; 95% CI 0.82 to 1.14), although LBW was decreased (unadjusted RR 0.56; 95% CI 0.46 to 0.69), but not in the adjusted data.
From our complete systematic review and meta-analyses, to our knowledge the first in this area, we conclude that short-statured women have higher unadjusted risks of PTB and LBW and tall women have approximately one half the unadjusted risk of LBW of women of reference height.
早产（PTB）和低出生体重（LBW）是新生儿发病和死亡的主要原因，但母亲身高对这些结局的影响仍存在争议。我们的目的是确定母亲身高与早产和低出生体重之间的关系。
检索了Medline和EMBASE自创建以来的文献。
纳入有参照组的研究，这些研究评估了母亲身高对单胎妊娠早产（<37周）和低出生体重（<2500克）的影响。
由两名审阅者独立提取数据。
纳入了56项研究，涉及333505名女性。在队列研究中，身材矮小女性早产的未调整风险增加（相对风险[RR]1.23；95%置信区间1.11至1.37），低出生体重的未调整风险也增加（RR 1.81；95%置信区间1.47至2.23），尽管并非所有有调整后数据的研究都发现了相同的关联。母亲身材高大与早产无关（未调整RR 0.97；95%置信区间0.82至1.14），尽管低出生体重有所降低（未调整RR 0.56；95%置信区间0.46至0.69），但在调整后数据中并非如此。
据我们所知，这是该领域的首次完整系统评价和荟萃分析，我们得出结论，身材矮小的女性早产和低出生体重的未调整风险较高，而身材高大的女性低出生体重的未调整风险约为参照身高女性的一半。
