Centre for Bioinformatics, School of Life Sciences, Pondicherry University, Pondicherry, India.
Neuroendocrinology. 2013;97(3):242-51. doi: 10.1159/000342694. Epub 2012 Oct 17.
Evolutionary rate variation in genes (proteins) is manifested both within the species (genome) and between the species (genomes). However, the interdependent components of a biological system in form of a gene or a protein are expected to evolve in a correlated manner under a common functional constraint.
The phylogenetic analysis and correlation analysis of gonadotropin-releasing hormone (GnRH) and gonadotropin-inhibitory hormone (GnIH) and their receptors (GnRHR and GnIHR) was conducted along with other control neuropeptides.
Both neuropeptides and their receptors regulating the reproductive neuroendocrine axis in vertebrates exhibited a correlated evolution under a common physiological constraint to regulate the release of gonadotropin. This result supports a coordinated substitution of amino acids in the GnRH and the GnIH neuropeptides along with their receptors in terms of similar evolutionary rates and distances with similar nucleotide composition of genes.
This is the first demonstration of the correlated evolution of two components of an endocrine system regulating the release of gonadotropin which are acting in concert for successful reproduction.
基因（蛋白质）的进化速率变化既表现在物种内（基因组内），也表现在物种间（基因组间）。然而，在共同的功能约束下，作为一个生物系统的组成部分的基因或蛋白质，其相关成分预计会以相关的方式进化。
对促性腺激素释放激素（GnRH）和促性腺激素抑制激素（GnIH）及其受体（GnRHR 和 GnIHR）与其他控制神经肽进行了系统发育分析和相关性分析。
在调节脊椎动物生殖神经内分泌轴的神经肽及其受体中，在调节促性腺激素释放的共同生理约束下，表现出相关进化。这一结果支持 GnRH 和 GnIH 神经肽及其受体的氨基酸在进化速率和距离上的相似性，以及基因核苷酸组成的相似性。
这是首次证明调节促性腺激素释放的内分泌系统的两个组成部分的相关进化，它们协同作用以实现成功繁殖。
