Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
Chem Commun (Camb). 2012 Oct 14;48(80):10049-51. doi: 10.1039/c2cc35644a.
The asymmetric synthesis of tetrahydropyridin-2-ols from enals and enaminones is described. The organocatalytic domino reaction involves a Michael addition-hemiaminalization sequence using the Jørgensen-Hayashi catalyst. Dehydration or oxidation leads to the corresponding 1,4-dihydro-pyridines or 3,4-dihydropyridin-2-ones in a one-pot fashion.
本文描述了由烯醛和烯胺酮不对称合成四氢吡啶-2-醇的方法。该有机催化串联反应涉及使用 Jørgensen-Hayashi 催化剂的迈克尔加成-半缩醛化序列。通过一锅法脱水或氧化，可以得到相应的 1,4-二氢吡啶或 3,4-二氢吡啶-2-酮。
