Sucker C, Korfmacher S, Papp-Váry M, Grieser C, Riess H
LaboMed Gerinnungszentrum Berlin, Tauentzienstr. 7b/c, 10789, Berlin, Deutschland.
Internist (Berl). 2012 Oct;53(10):1234-9. doi: 10.1007/s00108-012-3105-7.
The case of a 65-year-old woman with acquired hemophilia is reported. Acquired hemophilia is characterized by the development of inhibitors directed against coagulation factors. Impairment of plasmatic hemostasis leads to a severe bleeding tendency in individuals without a preexisting coagulation defect with considerable mortality. Pathophysiology, diagnostic work-up, and treatment are summarized and discussed.
报告了一例65岁获得性血友病女性患者的病例。获得性血友病的特征是出现针对凝血因子的抑制物。血浆止血功能受损会导致在无既往凝血缺陷的个体中出现严重出血倾向,并伴有相当高的死亡率。本文总结并讨论了其病理生理学、诊断检查及治疗方法。