Kogure Gislaine Satyko, Piccki Fabiene Karine, Vieira Carolina Sales, Martins Wellington de Paula, dos Reis Rosana Maria
Programa de Pós-Graduação em Biologia da Reprodução, Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
Rev Bras Ginecol Obstet. 2012 Jul;34(7):316-22. doi: 10.1590/s0100-72032012000700005.
To compare the metabolic parameters, body composition and muscle strength of women with Polycystic Ovary Syndrome (PCOS) to those of women with ovulatory menstrual cycles.
A case-control study was conducted on 27 women with PCOS and 28 control women with ovulatory cycles, aged 18 to 27 years with a body mass index of 18 to 39.9 kg/m², who did not practice regular physical activity. Serum testosterone, androstenedione, prolactin, sex hormone-binding globulin (SHBG), insulin and glycemia levels were determined. Free androgen index (FAI) and resistance to insulin (by HOMA) were calculated. The volunteers were submitted to evaluation of body composition based on skin folds and DEXA and to 1-RM maximum muscle strength tests in three exercises after familiarization procedures and handgrip isometric force was determined.
Testosterone levels were higher in the PCOS group than in the Control Group (68.07 ± 20.18 versus 58.20 ± 12.82 ng/dL; p=0.02), as also were the FAI (282.51 ± 223.86 versus 127.08 ± 77.19; p=0.01), insulin (8.41 ± 7.06 versus 4.05 ± 2.73 µIU/mL; p=0.01), and HOMA (2.3 ± 2.32 versus 1.06 ± 0.79; p=0.01), and SBHG levels were lower (52.51 ± 43.27 versus 65.45 ± 27.43 nmol/L; p=0.04). No significant differences in body composition were observed between groups using the proposed methods. The PCOS group showed greater muscle strength in the 1-RM test in the bench press (31.2 ± 4.75 versus 27.79 ± 3.63 kg; p=0.02), and leg extension exercises (27.9 ± 6.23 versus 23.47 ± 4.21 kg; p=0.02) as well as handgrip isometric force (5079.61 ± 1035.77 versus 4477.38 ± 69.66 kgf/m², p=0.04). PCOS was an independent predictor of increase muscle strength in bench press exercises (estimate (E)=2.7) (p=0.04) and leg extension (E=3.5) (p=0.04), and BMI in the exercise of isometric handgrip (E=72.2) (p<0.01), bench press (E=0.2) (p=0.02) and arm curl (E=0.3) (p<0.01). No association was found between HOMA-IR and muscle strength.
Women with POS showed greater muscle strength, with no difference in body composition, and IR was not associated with muscle strength performance. Muscle strength may be possibly related to high levels of androgens in these women.
比较多囊卵巢综合征（PCOS）女性与排卵性月经周期女性的代谢参数、身体成分和肌肉力量。
对27例PCOS女性和28例排卵周期正常的对照女性进行病例对照研究，年龄在18至27岁之间，体重指数为18至39.9kg/m²，且无规律体育活动。测定血清睾酮、雄烯二酮、催乳素、性激素结合球蛋白（SHBG）、胰岛素和血糖水平。计算游离雄激素指数（FAI）和胰岛素抵抗（通过HOMA）。志愿者在熟悉程序后，基于皮褶厚度和双能X线吸收法（DEXA）进行身体成分评估，并进行三项运动的1-RM最大肌肉力量测试，同时测定握力等长力。
PCOS组的睾酮水平高于对照组（68.07±20.18对58.20±12.82ng/dL；p=0.02），FAI（282.51±223.86对127.08±77.19；p=0.01）、胰岛素（8.41±7.06对4.05±2.73µIU/mL；p=0.01）和HOMA（2.3±2.32对1.06±0.79；p=0.01）也更高，而SHBG水平更低（52.51±43.27对65.45±27.43nmol/L；p=0.04）。使用所提出的方法，两组之间在身体成分方面未观察到显著差异。PCOS组在卧推1-RM测试（31.2±4.75对27.79±3.63kg；p=0.02）、腿部伸展运动（27.9±6.23对23.47±4.21kg；p=0.02）以及握力等长力（5079.61±1035.77对4477.38±69.66kgf/m²，p=0.04）方面表现出更大的肌肉力量。PCOS是卧推运动（估计值（E）=2.7）（p=0.04）和腿部伸展运动（E=3.5）（p=0.04）中肌肉力量增加的独立预测因素，以及在等长握力运动（E=72.2）（p<0.01）、卧推运动（E=0.2）（p=0.02）和弯举运动（E=0.3）（p<0.01）中的体重指数的独立预测因素。未发现HOMA-IR与肌肉力量之间存在关联。
患有PCOS的女性表现出更大的肌肉力量，身体成分无差异，且胰岛素抵抗与肌肉力量表现无关。这些女性的肌肉力量可能与雄激素水平升高有关。
