Division of Nanotechnology, Department of Measurement Technology and Industrial Electrical Engineering, Lund University, Lund, Sweden.
Electrophoresis. 2012 Nov;33(21):3143-50. doi: 10.1002/elps.201200134. Epub 2012 Sep 5.
The integrated selective enrichment target is a microfluidic platform for SPE sample preparation with integrated nanocolumns, which simultaneously offers direct MALDI MS read-out. Here, we present a study on the importance of different nanocolumn outlet hole geometries and hole areas in relation to MS signal intensity and reproducibility. A design solution that provides the flow characteristics required for robust sample preparation using automated liquid handling is reported.
整体选择性富集靶标是一种带有集成纳米柱的用于 SPE 样品制备的微流控平台，它还可以直接进行 MALDI MS 读取。在此，我们研究了不同纳米柱出口孔几何形状和孔面积对于 MS 信号强度和重现性的重要性。本文提出了一种设计方案，该方案提供了使用自动化液体处理进行稳健样品制备所需的流动特性。
