School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Depress Anxiety. 2012 Oct;29(10):843-9. doi: 10.1002/da.21995. Epub 2012 Sep 4.
Clinical trials have demonstrated the efficacy of internet cognitive behavioral therapy (iCBT) in the treatment of generalized anxiety disorder (GAD). The current study aims to determine whether these efficacy findings, established under controlled research conditions, translate into effectiveness in practice.
The sample comprised 588 patients who completed at least one iCBT lesson for GAD through CRUfAD clinic (www.crufadclinic.org). This six-lesson course became available to primary care physicians to prescribe in 2009. Routine data collection included demographics, GAD symptomatology (GAD-7), psychological distress (K-10), and disability (WHODAS).
All six lessons were completed by 324/588 (55.1%) patients. When compared with completers, noncompleters tended to be younger and based in rural locations. Prior to discontinuing the course, noncompleters demonstrated statistically significant reductions in psychological distress. For those who completed the course, effect sizes on all outcome measures were medium to large and over 60% of moderate-to-severe GAD cases met criteria for remission upon treatment completion.
The current study indicates that computerized CBT for GAD is effective in generating positive, clinically significant outcomes among typical patients treated under the usual conditions in primary care. Future research should focus on reducing treatment discontinuation among younger people and those based in rural locations.
临床试验已经证明了互联网认知行为疗法(iCBT)在治疗广泛性焦虑症(GAD)方面的疗效。本研究旨在确定这些在受控研究条件下得出的疗效发现是否转化为实践中的有效性。
该样本包括 588 名通过 CRUfAD 诊所(www.crufadclinic.org)完成至少一节 iCBT 课程的 GAD 患者。该六节课程于 2009 年开始提供给初级保健医生处方。常规数据收集包括人口统计学资料、GAD 症状(GAD-7)、心理困扰(K-10)和残疾(WHODAS)。
588 名患者中有 324 名(55.1%)完成了所有六节课程。与完成者相比,未完成者往往更年轻,且居住在农村地区。在停止课程之前,未完成者的心理困扰有统计学意义的显著降低。对于完成课程的患者,所有结局指标的效应大小均为中到大,超过 60%的中重度 GAD 病例在治疗完成时符合缓解标准。
本研究表明,针对 GAD 的计算机化 CBT 在常规初级保健中治疗典型患者时,能够产生积极的、具有临床意义的结果。未来的研究应侧重于减少年轻人和农村地区患者的治疗中断。