Yamanouchi H, Yanagisawa T, Takahashi M, Shimizu S, Hatakeyama S
Department of Pediatric Neurology, Gunma Children's Medical Center.
No To Hattatsu. 1990 Jan;22(1):77-81.
In 12-month-old girl with Krabbe's disease, serial CT and MRI examinations showed characteristic findings, which were symmetric high densities in globus pallidus and thalami before and during the course of brain atrophy and decreased attenuation in white matter. The low densities in white matter were not so remarkable as other degenerative diseases affecting primarily white matter. The high densities in the globus pallidus changed into low densities with progression of the white matter hypodensities and brain atrophy. These findings on CT in Krabbe's disease may assist neurologists in narrowing the differential diagnosis and requesting appropriate laboratory tests.
在一名患有克拉伯病的12个月大女孩中，系列CT和MRI检查显示出特征性表现，即在脑萎缩之前及过程中苍白球和丘脑呈对称性高密度，白质衰减降低。白质中的低密度不像其他主要影响白质的退行性疾病那样明显。随着白质低密度和脑萎缩的进展，苍白球中的高密度变为低密度。克拉伯病的这些CT表现可能有助于神经科医生缩小鉴别诊断范围并要求进行适当的实验室检查。
