Winants D, Bernard C, Galloy M A, Hoeffel J C, Vidailhet M
Service de Radiologie, Hôpital d'Enfants, Vandoeuvre.
J Radiol. 1988 Nov;69(11):697-700.
Krabbe's disease whose CT appearance is well known should benefit of the development of MRI as this method is more accurate. MRI permits early diagnosis of leucodystrophy. Yet it must be emphasized that abnormal white matter patterns are not sufficient to permit the diagnosis of Krabbe disease. In the case reported atrophy of the brain, the cerebellum and the brain-stem, demyelination of the white matter and necrosis of corpus callosum were observed. The abnormalities of the brain on MRI pictures help in the diagnosis as they may alert clinicians to the possibility of Krabbe disease in infants with progressive encephalopathy. A definitive diagnosis can be established thanks to the laboratory tests.
克拉伯病的CT表现已为人熟知，随着更精确的MRI技术的发展，其诊断应会从中受益。MRI能够对脑白质营养不良进行早期诊断。然而必须强调的是，仅白质异常模式不足以确诊克拉伯病。在报道的病例中，观察到脑、小脑和脑干萎缩，白质脱髓鞘以及胼胝体坏死。MRI图像上的脑部异常有助于诊断，因为它们可能提醒临床医生，患有进行性脑病的婴儿有患克拉伯病的可能性。借助实验室检查可做出明确诊断。
