Department of Clinical Therapeutics, Athens Medical School, Alexandra Hospital, Athens, Greece.
In Vivo. 2012 Sep-Oct;26(5):869-73.
The purpose of the present study was to examine the effect of SonoVue™ on right ventricular (RV) dimensions and contractility in patients with heart failure.
Twenty-four patients were divided into two groups. Group A consisted of 15 patients with heart failure and group B (control) of nine patients without heart disease. SonoVue was administered at low (2 ml) and high (4 ml) doses in both groups separately, in a random order. RV dimensions, contractility, peak systolic pressure gradient from tricuspid regurgitation (TRPG) and the time to maximal RV end-diastolic dimension (EDD), as well as the time for RV-EDD to return to the baseline value (recovery), were calculated in every cardiac cycle starting before the administration of SonoVue (baseline) until the recovery of RV-EDD.
Low-(group A, p<0.001 and group B, p<0.05) and high-dose (group A, p<0.0001 and group B, p<0.01) contrast infusion increased the RV-EDD compared to baseline values. TRPG increased significantly (p<0.05) in both groups, under low-as well as high-dose. In group A, high-dose compared to low-dose produced a significant delay in the time duration to max RV-EDD (p<0.05) and in the time to RV-EDD recovery (p<0.0001).
The administration of SonoVue in patients with heart failure was followed by an acute, transient, dose-dependent increase in RV-EDD and TRPG, without any effect on RV contractility.
本研究旨在观察 SonoVue 在心力衰竭患者右心室（RV）尺寸和收缩功能中的作用。
24 名患者分为两组。A 组 15 名心力衰竭患者，B 组（对照组）9 名无心脏病患者。两组均分别以低（2ml）和高（4ml）剂量随机使用 SonoVue。在 SonoVue 给药前（基线）直至 RV-EDD 恢复到基线值（恢复）的每个心动周期中计算 RV 尺寸、收缩力、三尖瓣反流（TR）的收缩期峰值压力梯度（TRPG）和 RV-EDD 达到最大值的时间以及 RV-EDD 恢复到基线值的时间（恢复）。
低剂量（A 组，p<0.001 和 B 组，p<0.05）和高剂量（A 组，p<0.0001 和 B 组，p<0.01）造影剂输注均使 RV-EDD 与基线值相比增加。TRPG 在两组低剂量和高剂量下均显著增加（p<0.05）。在 A 组中，与低剂量相比，高剂量在 RV-EDD 达到最大值的时间（p<0.05）和 RV-EDD 恢复时间（p<0.0001）上明显延迟。
心力衰竭患者使用 SonoVue 后，RV-EDD 和 TRPG 出现急性、短暂、剂量依赖性增加，但对 RV 收缩力无影响。
