Mandahl N, Heim S, Arheden K, Rydholm A, Willén H, Mitelman F
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Cancer. 1990 Jan 15;65(2):242-8. doi: 10.1002/1097-0142(19900115)65:2<242::aid-cncr2820650211>3.0.co;2-l.
Short-term cultures from 16 chondromatous tumors, 15 primary and one recurrent, were analyzed cytogenetically. Clonal chromosome aberrations were found in one of six benign tumors and in seven of ten malignant tumors. A chondroma had a complex translocation involving chromosomes X, 8, 12, and 13, as well as a deletion of the derivative chromosome 8. In the malignant tumors, monosomy 6 and 22 were observed in three tumors and monosomy 10, 11, 13, and 18 were observed in two tumors. In two of the three metastasizing tumors, del(5) (q13) and loss of chromosomes 6, 10, 11, 13, and 22 were common features. Structural aberrations of chromosome 1 were found in five tumors, of chromosomes 6, 12, and 15 in three tumors, and of chromosomes 4, 5, 9, and 20 in two tumors. We conclude that although considerable cytogenetic heterogeneity exists among chondromatous tumors, the karyotypic anomalies are still nonrandom.
对16例软骨瘤性肿瘤（15例原发性和1例复发性）的短期培养物进行了细胞遗传学分析。在6例良性肿瘤中的1例以及10例恶性肿瘤中的7例发现了克隆性染色体畸变。1例软骨瘤有涉及X、8、12和13号染色体的复杂易位，以及衍生8号染色体的缺失。在恶性肿瘤中，3例肿瘤观察到6号和22号染色体单体性，2例肿瘤观察到10、11、13和18号染色体单体性。在3例发生转移的肿瘤中的2例，del(5)(q13)以及6、10、11、13和22号染色体缺失是常见特征。1号染色体的结构畸变在5例肿瘤中发现，6、12和15号染色体的结构畸变在3例肿瘤中发现，4、5、9和20号染色体的结构畸变在2例肿瘤中发现。我们得出结论，尽管软骨瘤性肿瘤之间存在相当大的细胞遗传学异质性，但核型异常仍然是非随机的。
