School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Trends Cell Biol. 2012 Nov;22(11):592-601. doi: 10.1016/j.tcb.2012.08.002. Epub 2012 Aug 30.
Cell proliferation is regulated by multiple signaling pathways and stress surveillance systems to ensure cell division takes place with fidelity. In response to oxidative stress, cells arrest in the cell-cycle and aberrant redox control of proliferation underlies the pathogenesis of many diseases including cancer and neurodegenerative disorders. Redox sensing of cell-cycle regulation has recently been shown to involve reactive cysteine thiols that function as redox sensors in cell-cycle regulators. By modulating cell-cycle regulators these redox-active thiols ensure cell division is executed at the right redox environment. This review summarizes recent findings on regulation of cell division by the oxidation of cysteines in cell division regulators and the potential of targeting these critical cysteine residues for cancer therapy.
细胞增殖受多种信号通路和应激监测系统的调节，以确保细胞分裂的忠实性。在氧化应激的情况下，细胞会在细胞周期中停滞，而增殖的异常氧化还原控制是许多疾病（包括癌症和神经退行性疾病）的发病基础。最近的研究表明，细胞周期调节的氧化还原感应涉及反应性半胱氨酸巯基，它们在细胞周期调节剂中充当氧化还原传感器。通过调节细胞周期调节剂，这些氧化还原活性的巯基确保细胞分裂在正确的氧化还原环境中进行。这篇综述总结了细胞分裂调节剂中半胱氨酸氧化对细胞分裂的调控作用的最新发现，以及针对这些关键半胱氨酸残基进行癌症治疗的潜力。
