Fox Paul A
Chelsea & Westminster Hospital, London SW10 9NH, UK.
Sex Health. 2012 Dec;9(6):587-92. doi: 10.1071/SH11157.
There is a growing range of treatment options for anal intraepithelial neoplasia (AIN). In HIV-positive patients, sustained treatment is often required to achieve clearance. The treatments considered are topically applied fluorouracil, imiquimod, cidofovir and trichloroacetic acid, the potential treatments of topical lopinavir and photodynamic therapy with aminolevulenic acid, and the surgical methods of electrosurgery, infrared coagulation and laser. Destructive treatment methods, possibly including TCA, are more effective than self applied topical treatments. Combining or alternating different treatments should be considered.
对于肛管上皮内瘤变（AIN），治疗选择的范围正在不断扩大。在HIV阳性患者中，通常需要持续治疗以实现清除。所考虑的治疗方法包括局部应用氟尿嘧啶、咪喹莫特、西多福韦和三氯乙酸，局部应用洛匹那韦的潜在治疗方法以及用氨基乙酰丙酸进行光动力疗法，还有电外科手术、红外凝固术和激光等手术方法。可能包括三氯乙酸的破坏性治疗方法比自行应用的局部治疗更有效。应考虑联合或交替使用不同的治疗方法。
