Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
Cold Spring Harb Perspect Med. 2012 Sep 1;2(9):a006550. doi: 10.1101/cshperspect.a006650.
The angiopoietin-Tie signaling system is a vascular-specific receptor tyrosine kinase pathway that is essential for normal vascular development. Although the basic functioning of the pathway is understood, many uncertainties remain about the role of certain members of the pathway, particularly angiopoietin-2 (Ang2), in pathological vascular remodeling and angiogenesis. We summarize the components of the angiopoietin-Tie pathway and then focus on studies that highlight the role of Ang2 in disease settings, including cancer and inflammation. The expression of Ang2 is elevated in many cancers and types of inflammation, which prompted the development of specific reagents to block its interaction with the Tie2 receptor. The application of these reagents in preclinical models of inflammation and cancer has begun to elucidate the role of Ang2 in vascular remodeling and disease pathogenesis and has led to emerging clinical tests of Ang2 inhibitors.
血管生成素-Tie 信号系统是一种血管特异性受体酪氨酸激酶通路，对于正常的血管发育至关重要。尽管该通路的基本功能已被理解，但关于该通路的某些成员（特别是血管生成素-2（Ang2））在病理性血管重塑和血管生成中的作用仍然存在许多不确定性。我们总结了血管生成素-Tie 通路的组成部分，然后重点介绍了强调 Ang2 在疾病环境中作用的研究，包括癌症和炎症。Ang2 的表达在许多癌症和炎症类型中升高，这促使开发了专门的试剂来阻断其与 Tie2 受体的相互作用。这些试剂在炎症和癌症的临床前模型中的应用已经开始阐明 Ang2 在血管重塑和疾病发病机制中的作用，并导致 Ang2 抑制剂的新兴临床测试。
