Koc University School of Medicine, Istanbul, Turkey.
Clin Hemorheol Microcirc. 2013;53(1-2):61-70. doi: 10.3233/CH-2012-1576.
Comparative data on blood composition and blood flow properties indicate different levels of interspecies variation for several parameters. Hematocrit and hemoglobin levels have relatively low variability among mammals, while mean cell volume and red blood cell (RBC) count are more variable. There is also a difference of variability between high and low shear rate blood viscosity in mammals, with low shear rate viscosity having a higher degree of interspecies variation. This observation parallels the diversity of RBC aggregation among mammalian species. Allometric relations for blood rheology parameters indicate highly significant correlations of low shear rate blood viscosity and RBC aggregation with body weight, especially if species belonging to the order Artiodactyla are excluded. These allometric relations can be used to formulate various hypotheses about the evolutionary histories of circulatory functions, as well as hypotheses related to the role of RBC aggregation in the mammalian circulatory system. Such comparative studies and analytical reasoning based on comparative data may contribute to answering the "why" questions, and accordingly may improve our understanding of circulatory functions and hence may have possible clinical importance. During the last several decades, similar approaches to various medical concepts have yielded a new approach to medicine that is now known as Evolutionary Medicine.
比较血液成分和血液流动特性的数据表明，几个参数在种间存在不同的变化水平。血细胞比容和血红蛋白水平在哺乳动物中相对变化较小，而平均细胞体积和红细胞（RBC）计数的变化较大。在哺乳动物中，高剪切率和低剪切率血液粘度之间也存在可变性的差异，低剪切率粘度的种间变化程度更高。这种观察结果与哺乳动物物种中 RBC 聚集的多样性相平行。血液流变学参数的比较关系表明，低剪切率血液粘度和 RBC 聚集与体重高度相关，尤其是如果排除偶蹄目动物的物种。这些比较关系可以用来制定关于循环功能进化历史的各种假说，以及与 RBC 聚集在哺乳动物循环系统中的作用相关的假说。这种比较研究和基于比较数据的分析推理有助于回答“为什么”的问题，因此可能有助于我们更好地理解循环功能，从而可能具有重要的临床意义。在过去几十年中，对各种医学概念的类似方法产生了一种新的医学方法，现在称为进化医学。
