Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, Ljubljana, Slovenia.
Int J Pharm. 2012 Nov 1;437(1-2):294-302. doi: 10.1016/j.ijpharm.2012.08.013. Epub 2012 Aug 19.
The preparation of microcapsules with a self-microemulsifying system (SMES) core using a vibrating nozzle technology was improved with regard to process reproducibility and core phase retention. The microcapsule shell was optimized for composition of the alginate-pectin (A/P) ratio and hydrophilic filling agent content. The best-shaped microcapsules with highest encapsulation efficiency for furosemide-loaded SMES were obtained from the shell-formation phase with an A/P ratio of 25:75, containing 10% lactose, which was hardened through a one-step process. Fluid-bed dried microcapsules were examined for their release characteristics and swelling behavior of the polymeric matrix. Incorporation of hydrophilic filling agents in the shell-formation phase was shown to be successful in limiting the leakage of the core phase during the microcapsule production and drying processes. Moreover, the addition of different fillers also allows the drug release profile from Ca-alginate/pectinate microcapsules with a self-microemulsifying core to be modified.
采用振动喷嘴技术，利用自微乳化系统（SMES）芯体制备微胶囊，提高了工艺重现性和芯相保留率。优化了海藻酸钠-果胶（A/P）比例和亲水性填充剂含量的微胶囊壳组成。从壳形成相中获得了最佳形状的微胶囊，其包封效率最高，可用于装载呋塞米的 SMES，A/P 比为 25:75，含有 10%乳糖，通过一步法硬化。流化床干燥的微胶囊的释放特性和聚合物基质的溶胀行为进行了检查。在壳形成相中加入亲水性填充剂，成功地限制了芯相在微胶囊生产和干燥过程中的泄漏。此外，添加不同的填充物也可以改变具有自微乳化核心的 Ca-海藻酸盐/果胶微胶囊的药物释放曲线。
