一名接受干扰素α-2a治疗白塞病的患者出现白癜风。

Vitiligo in a Patient Treated with Interferon Alpha-2a for Behçet's Disease.

作者信息

Guney Esra, Akcali Gulunay, Akcay Betul Ilkay, Unlu Cihan, Erdogan Gurkan, Bozkurt Tahir Kansu, Bayramlar Huseyin

机构信息

Ophthalmology Clinic, Umraniye Research and Education Hospital, Adem Yavuz Caddesi, Ümraniye, İstanbul, Turkey.

出版信息

Case Rep Med. 2012;2012:387140. doi: 10.1155/2012/387140. Epub 2012 Aug 16.

DOI:10.1155/2012/387140

PMID:22952476

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3431079/

Abstract

Behçet's disease (BD) and vitiligo are diseases of unknown etiology. Interferon (IFN) alpha therapy is commonly used in Behçet uveitis. Interferon treatment in various diseases have also been observed causing certain autoimmune diseases such as vitiligo because of its immunomodulatory activity. The association between IFN therapy and vitiligo has been reported in the literature. We report a 21-year-old man with BD in whom vitiligo occurred during IFN treatment. To the best of our knowledge, this is the first reported case of such an association.

摘要

白塞病（BD）和白癜风是病因不明的疾病。干扰素（IFN）α疗法常用于白塞葡萄膜炎。由于其免疫调节活性，在各种疾病中使用干扰素治疗也观察到会引发某些自身免疫性疾病，如白癜风。文献中已报道了干扰素治疗与白癜风之间的关联。我们报告一名21岁患有白塞病的男性，其在干扰素治疗期间出现了白癜风。据我们所知，这是首例报道的此类关联病例。