Department of Mechanical Engineering, Hanyang University, Ansan, Korea.
Saf Health Work. 2011 Mar;2(1):65-9. doi: 10.5491/SHAW.2011.2.1.65. Epub 2011 Mar 31.
Carbon nanotubes are an important new class of technological materials that have numerous novel and useful properties. Multi-walled carbon nanotubes (MWCNTs), which is a nanomaterial, is now in mass production because of its excellent mechanical and electrical properties. Although MWCNTs appear to have great industrial and medical potential, there is little information regarding their toxicological effects on researchers and workers who could be exposed to them by inhalation during the handling of MWCNTs.
The generation of an untangled MWCNT aerosol with a consistent concentration without using surfactants that was designed to be tested in in vivo inhalation toxicity testing was attempted. To do this, MWCNTs were dispersed in deionized water without the addition of any surfactant. To facilitate the dispersion of MWCNTs in deionized water, the water was heated to 40℃, 60℃, and 80℃ depending on the sample with ultrasonic sonication. Then the dispersed MWCNTs were atomized to generate the MWCNT aerosol. After aerosolization of the MWCNTs, the shapes of the NTs were examined by transmission electron microscopy.
The aerosolized MWCNTs exhibited an untangled shape and the MWCNT generation rate was about 50 mg/m(3).
Our method provided sufficient concentration and dispersion of MWNCTs to be used for inhalation toxicity testing.
碳纳米管是一类具有众多新颖有用特性的重要新型技术材料。多壁碳纳米管（MWCNTs）是一种纳米材料，由于其优异的机械和电气性能，现已大规模生产。尽管 MWCNTs 似乎具有巨大的工业和医疗潜力，但关于它们对可能通过吸入在处理 MWCNTs 过程中接触到它们的研究人员和工人的毒理学影响的信息却很少。
尝试生成一种无缠结的 MWCNT 气溶胶，该气溶胶具有一致的浓度，而无需使用表面活性剂，这是为体内吸入毒性测试而设计的。为此，MWCNTs 在未添加任何表面活性剂的去离子水中分散。为了促进 MWCNTs 在去离子水中的分散，根据样品将水加热至 40℃、60℃和 80℃，并用超声波处理。然后将分散的 MWCNTs 雾化以生成 MWCNT 气溶胶。MWCNTs 雾化后，通过透射电子显微镜检查 NTs 的形状。
雾化的 MWCNTs 呈现出无缠结的形状，MWCNT 的生成速率约为 50mg/m³。
我们的方法为吸入毒性测试提供了足够浓度和分散的 MWCNTs。
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