Vanhoutte Sarah, De Letter Miet, Corthals Paul, Van Borsel John, Santens Patrick
Department of Neurology, Ghent University Hospital, Belgium.
Clin Linguist Phon. 2012 Oct;26(10):863-81. doi: 10.3109/02699206.2012.711420.
The present study examined language production skills in Parkinson's disease (PD) patients. A unique cued sentence generation task was created in order to reduce demands on memory and attention. Differences in sentence production abilities according to disease severity and cognitive impairments were assessed. Language samples were obtained from 20 PD patients and 20 healthy control participants matched for age, sex and educational level. In addition, a cognitive test for verbal memory and resistance to cognitive interference was administered. Statistical comparisons revealed significant language changes in an advanced stage of the disease. Advanced PD patients showed a reduction in lexical diversity in notional verbs, which was absent in nouns. Cognitive dysfunctions such as impaired verbal memory are suggested to contribute to the typical noun/verb dissociation in PD patients. In addition, advanced PD patients produced more semantic perseverations, which may be related to set-switching problems. In conclusion, whether language disturbances in PD are the result of non-linguistic cognitive dysfunctions or reflect pure language deficits exacerbated by cognitive impairments, remains a matter of debate. However, the negative impact of cognitive dysfunctions may be important.
本研究考察了帕金森病（PD）患者的语言生成技能。为了减少对记忆和注意力的要求，创建了一项独特的提示句子生成任务。评估了根据疾病严重程度和认知障碍在句子生成能力方面的差异。从20名PD患者和20名年龄、性别和教育水平相匹配的健康对照参与者中获取语言样本。此外，还进行了一项关于言语记忆和认知干扰抵抗力的认知测试。统计比较显示在疾病晚期存在显著的语言变化。晚期PD患者在实义动词方面的词汇多样性降低，而名词方面则没有。言语记忆受损等认知功能障碍被认为是导致PD患者典型的名词/动词分离的原因。此外，晚期PD患者产生了更多的语义持续现象，这可能与定势转换问题有关。总之，PD中的语言障碍是由于非语言认知功能障碍的结果还是反映了由认知障碍加剧的纯语言缺陷，仍存在争议。然而，认知功能障碍的负面影响可能很重要。
