Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan.
Respir Med. 2012 Nov;106(11):1566-74. doi: 10.1016/j.rmed.2012.07.012. Epub 2012 Sep 4.
This study took advantage of a large population-based database of the Taiwan National Health Insurance (NHI) to investigate the epidemiology of idiopathic pulmonary fibrosis (IPF) in Taiwan.
This is a retrospective cohort study based on secondary analysis of prospectively collected data in the NHI system and governmental data on death registry in Taiwan during 1997-2007. By using the broad and narrow definitions for IPF, we estimated incidence and prevalence rates of IPF, and its associated clinical outcomes.
The estimates of annual IPF incidence rates became more stable after 2000, ranging between 0.9 and 1.6 cases per 100,000 persons. The prevalence rates became more than twofold from 2000 to 2007 (from 2.8 to 6.4 cases per 100,000 persons for the broad definition, and from 2.0 to 4.9 cases per 100,000 persons for the narrow definition). Men of age older than 75 years had markedly higher incidence and prevalence rates than other groups. Around 40% of all incidences and about 30% of prevalent cases occurred in this population group. The median survival time after IPF diagnosis was 0.9 year (interquartile range (IQR), 0.2-2.5 years) and 0.7 year (IQR, 0.1-2.3 years) for the broad and narrow definitions, respectively. Progression of IPF was the leading cause of death, followed by cancer.
In Taiwan, elderly men were the major group suffering from IPF. Survival time was short after IPF diagnosis, and the poor survival was largely attributable to quick IPF progression after diagnosis.
本研究利用台湾全民健康保险（NHI）的大型基于人群的数据库，调查了台湾特发性肺纤维化（IPF）的流行病学情况。
这是一项基于回顾性队列研究，对 NHI 系统中前瞻性收集的数据和台湾政府关于 1997-2007 年死亡登记的数据进行二次分析。通过使用 IPF 的广义和狭义定义，我们估算了 IPF 的发病率和患病率，并评估了其相关的临床结局。
2000 年后，IPF 的年发病率估计值变得更加稳定，范围在每 10 万人中 0.9 至 1.6 例之间。2000 年至 2007 年，患病率增加了一倍以上（广义定义下从每 10 万人 2.8 例增加到 6.4 例，狭义定义下从每 10 万人 2.0 例增加到 4.9 例）。年龄大于 75 岁的男性发病率和患病率明显高于其他人群。所有发病的 40%左右和约 30%的现患病例发生在该人群中。IPF 诊断后中位生存时间为 0.9 年（四分位间距（IQR），0.2-2.5 年）和 0.7 年（IQR，0.1-2.3 年），分别用于广义和狭义定义。IPF 的进展是死亡的主要原因，其次是癌症。
在台湾，老年男性是患 IPF 的主要人群。IPF 诊断后生存时间较短，诊断后 IPF 迅速进展是生存不良的主要原因。
