SAPIN：蛋白质相互作用网络结构分析框架。
SAPIN: a framework for the structural analysis of protein interaction networks.
机构信息
EMBL/CRG, Design of Biological Systems, Systems Biology Research Unit, Centre for Genomic Regulation-CRG, UPF, 08003 Barcelona, Spain.
出版信息
Bioinformatics. 2012 Nov 15;28(22):2998-9. doi: 10.1093/bioinformatics/bts539. Epub 2012 Sep 6.
SUMMARY
Protein interaction networks are widely used to depict the relationships between proteins. These networks often lack the information on physical binary interactions, and they do not inform whether there is incompatibility of structure between binding partners. Here, we introduce SAPIN, a framework dedicated to the structural analysis of protein interaction networks. SAPIN first identifies the protein parts that could be involved in the interaction and provides template structures. Next, SAPIN performs structural superimpositions to identify compatible and mutually exclusive interactions. Finally, the results are displayed using Cytoscape Web.
AVAILABILITY
The SAPIN server is available at http://sapin.crg.es.
CONTACT
jae-seong.yang@crg.eu or christina.kiel@crg.eu.
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics Online.
摘要
蛋白质相互作用网络被广泛用于描绘蛋白质之间的关系。这些网络通常缺乏关于物理二元相互作用的信息，也没有告知结合伴侣之间是否存在结构不兼容性。在这里，我们介绍了 SAPIN，这是一个专门用于蛋白质相互作用网络结构分析的框架。SAPIN 首先识别可能参与相互作用的蛋白质部分，并提供模板结构。接下来，SAPIN 进行结构叠加以识别兼容和互斥的相互作用。最后，结果使用 Cytoscape Web 显示。
可用性
SAPIN 服务器可在 http://sapin.crg.es 上获得。
联系方式
jae-seong.yang@crg.eu 或 christina.kiel@crg.eu。
补充信息
补充数据可在 Bioinformatics Online 上获得。
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