Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.
J Alzheimers Dis. 2013;33(2):317-21. doi: 10.3233/JAD-2012-121312.
Previous studies have suggested a pathogenetic role of autoantibodies (Abs) against ATP synthase (ATPs) in patients with Alzheimer's disease (AD). Using a mouse model, we found that intracerebroventricular administration of anti-ATPs-Abs, purified from AD patients, leads to poor cognitive performance and pronounced cell damage in the hippocampus, a brain region specifically involved in learning and memory processes, which is severely affected in AD. Our results are suggestive of a role of anti-ATPs-Abs in the onset and progression of AD and also provide a fruitful model for the study of memory disturbances in neurodegenerative diseases.
先前的研究表明，针对三磷酸腺苷合成酶（ATPs）的自身抗体（Abs）在阿尔茨海默病（AD）患者中具有致病作用。通过使用小鼠模型，我们发现，将从 AD 患者中纯化的针对 ATPs 的 Abs 注入侧脑室，会导致认知能力下降和海马体（大脑中专门参与学习和记忆过程的区域，AD 患者的该区域会受到严重影响）的细胞损伤。我们的研究结果提示，针对 ATPs 的 Abs 在 AD 的发病和进展中起作用，同时为研究神经退行性疾病中的记忆障碍提供了一个富有成效的模型。
