Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21224, USA.
Curr Opin Rheumatol. 2012 Nov;24(6):602-8. doi: 10.1097/BOR.0b013e328358bd85.
To review recent advances in our understanding of autoantibodies associated with dermatomyositis and the autoimmune necrotizing myopathies.
Autoantibodies preferentially associated with dermatomyositis include those recognizing Mi-2, MDA5, TIF1γ, and NXP-2. Each of these is associated with a distinct clinical phenotype. Autoantibodies found in patients with autoimmune necrotizing myopathies recognize signal recognition particle and 3-hydroxy-3-methylglutaryl-coenzime A reductase (HMG-CoA) reductase. The latter are found in patients with statin-associated autoimmune muscle disease.
As these are helpful both diagnostically and prognostically, a rheumatologist should be familiar with autoantibodies found in patients with dermatomyositis and the autoimmune necrotizing myopathies.
回顾自身免疫性肌炎和自身免疫性坏死性肌病相关自身抗体的最新研究进展。
特异地与皮肌炎相关的自身抗体包括识别 Mi-2、MDA5、TIF1γ 和 NXP-2 的抗体。每种抗体都与独特的临床表型相关。自身免疫性坏死性肌病患者的自身抗体识别信号识别颗粒和 3-羟基-3-甲基戊二酰基辅酶 A 还原酶（HMG-CoA）还原酶。后者存在于他汀类药物相关自身免疫性肌肉疾病患者中。
由于这些抗体在诊断和预后方面都有帮助，因此风湿病医生应该熟悉皮肌炎和自身免疫性坏死性肌病患者的自身抗体。
